Note: This document contains side effect information about acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Duraflu.

Applies to acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine: oral capsule, oral powder for reconstitution, oral tablet.

Get emergency medical help if you have any of these signs of an allergic reaction while taking acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using this medicine and call your doctor at once if you have:

• chest pain;

• fast, slow, or uneven heart rate;

• severe dizziness, feeling like you might pass out;

• mood changes, confusion, hallucinations, tremor, seizure (convulsions);

• fever;

• little or no urinating;

• nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or

• dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).

Common side effects may include:

• dizziness, weakness;

• mild headache;

• mild nausea, diarrhea, upset stomach;

• dry mouth, nose, or throat;

• feeling nervous, restless, irritable, or anxious; or

• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.