Applies to senna: oral solution, oral tablets and chewable pieces.

Side effects include:

Abdominal discomfort, nausea, mild cramps, griping, faintness.

For Healthcare Professionals

Applies to senna: compounding powder, oral disintegrating strip, oral granule, oral liquid, oral syrup, oral tablet, oral tablet chewable, rectal suppository.

Gastrointestinal

Abdominal pain, abdominal spasm, and liquid stool passage usually occurred in patients with irritable colon and may occur in individual overdose events; dose reductions should be performed if the side effects occur.

Chronic use may result in intestinal mucosa pigmentation/pseudomelanosis coli, which usually recedes with treatment discontinuation.^[Ref]

Frequency not reported: Abdominal pain, abdominal spasm, diarrhea, gastrointestinal tract mucosal pigmentation, intestinal mucosa pigmentation, liquid stool passage, pseudomelanosis coli^[Ref]

Genitourinary

Frequency not reported: Albuminuria, chromaturia, hematuria, pH-dependent urine metabolite discoloration, red-brown urine metabolite discoloration, yellow urine metabolite discoloration^[Ref]

Albuminuria and hematuria may occur as a result of electrolyte and water equilibrium disorders.

Urine discoloration by metabolites was not clinically significant.^[Ref]

Dermatologic

Frequency not reported: Generalized exanthema, localized exanthema, pruritus, urticaria^[Ref]

Metabolic

Chronic use may result in electrolyte metabolism and water equilibrium disorders.^[Ref]

Frequency not reported: Cachexia, electrolyte metabolism disorder, hypokalemia, tetany, water equilibrium disorder^[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity/hypersensitivity reactions^[Ref]

Hypersensitivity reactions included generalized/local exanthema, pruritus, and/or urticaria.^[Ref]

Musculoskeletal

Frequency not reported: Finger clubbing, hypertrophic osteoarthropathy^[Ref]

Immunologic

Frequency not reported: Hypogammaglobulinemia^[Ref]

Respiratory

Frequency not reported: Asthma^[Ref]