Summary

Commonly reported side effects of famotidine/ibuprofen include: increased serum alanine aminotransferase and increased serum aspartate aminotransferase. Continue reading for a comprehensive list of adverse effects.

Applies to famotidine / ibuprofen: oral tablet.

Serious side effects

Along with its needed effects, famotidine / ibuprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking famotidine / ibuprofen:

Less common

• Bladder pain
• bloating or swelling of the face, arms, hands, lower legs, or feet
• bloody or black, tarry stools
• blurred vision
• chills
• clay-colored stools
• cloudy urine
• constipation
• cough
• dark-colored urine
• diarrhea
• difficult, burning, or painful urination
• dizziness
• fever
• frequent urge to urinate
• general feeling of discomfort or illness
• headache
• heartburn
• indigestion
• itching or rash
• joint pain
• light-colored stools
• loss of appetite
• lower back or side pain
• muscle aches and pains
• nausea
• nervousness
• pale skin
• pounding in the ears
• rapid weight gain
• runny nose
• severe stomach pain
• shivering
• slow or fast heartbeat
• sore throat
• stomach pain, cramping, or burning
• sweating
• tingling of the hands or feet
• trouble sleeping
• trouble breathing
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss
• vomiting
• vomiting of blood or material that looks like coffee grounds
• yellow eyes or skin

Incidence not known

• Blistering, peeling, or loosening of the skin
• change in consciousness
• confusion as to time, place, or person
• cracks in the skin
• darkening of the skin
• depression
• dry mouth
• fainting
• hallucinations
• holding false beliefs that cannot be changed by fact
• loss of consciousness
• loss of heat from the body
• pain in the lower back or side
• pain in the chest, groin, or legs, especially calves of the legs
• red skin lesions, often with a purple center
• red, irritated eyes
• red, swollen skin
• scaly skin
• seizures
• severe headaches of sudden onset
• sores, ulcers, or white spots in the mouth or on the lips
• stiff neck or back
• sudden loss of coordination
• sudden onset of slurred speech
• sudden vision changes
• swollen glands
• thirst
• unusual excitement, nervousness, or restlessness

Other side effects

Some side effects of famotidine / ibuprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Back pain
• belching
• body aches or pain
• cough producing mucus
• difficulty having a bowel movement
• difficulty with moving
• ear congestion
• loss of voice
• muscle stiffness
• pain or tenderness around the eyes and cheekbones
• sneezing
• stuffy nose

For Healthcare Professionals

Applies to famotidine / ibuprofen: oral tablet.

General

Famotidine-Ibuprofen:

The most frequently reported side effects included nausea, diarrhea, constipation, upper abdominal pain, and headache.^[Ref]

Gastrointestinal

Famotidine-Ibuprofen:

Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain

Famotidine:

Postmarketing reports: Nausea, diarrhea, vomiting, abdominal pain

Ibuprofen:

Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain^[Ref]

Cardiovascular

Famotidine-Ibuprofen:

Common (1% to 10%): Hypertension

Famotidine:

Postmarketing reports: Hypotension

Ibuprofen:

Common (1% to 10%): Hypertension

Postmarketing reports: Myocardial infarction^[Ref]

Renal

Famotidine-Ibuprofen:

Common (1% to 10%): Serum creatinine increased

Frequency not reported: Acute renal failure

Ibuprofen:

Common (1% to 10%): Serum creatinine increased

Postmarketing reports: Acute renal failure^[Ref]

Hematologic

Famotidine-Ibuprofen:

Common (1% to 10%): Anemia

Famotidine:

Postmarketing reports: Anemia, thrombocytopenia, platelet count decreased, hemoglobin decreased

Ibuprofen:

Common (1% to 10%): Anemia^[Ref]

Hepatic

Famotidine:

Postmarketing reports: Hepatic function abnormal, ALT increased, AST increased

Other

Famotidine-Ibuprofen:

Common (1% to 10%): Peripheral edema, influenza

Famotidine:

Postmarketing reports: Pyrexia, condition aggravated, asthenia, drug ineffective, chest pain, fatigue, pain, peripheral edema, sepsis

Ibuprofen:

Common (1% to 10%): Peripheral edema, influenza

Postmarketing reports: Pyrexia, pain, fatigue, asthenia, chest pain, drug ineffective^[Ref]

Metabolic

Famotidine:

Postmarketing reports: Appetite decreased^[Ref]

Musculoskeletal

Famotidine-Ibuprofen:

Common (1% to 10%): Arthralgia, back pain

Ibuprofen:

Common (1% to 10%): Arthralgia, back pain^[Ref]

Nervous system

Famotidine-Ibuprofen:

Common (1% to 10%): Headache

Famotidine:

Postmarketing reports: Dizziness, headache

Ibuprofen:

Common (1% to 10%): Headache

Postmarketing reports: Dizziness^[Ref]

Respiratory

Famotidine-Ibuprofen:

Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain

Famotidine:

Postmarketing reports: Pneumonia, dyspnea

Ibuprofen:

Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain

Postmarketing reports: Dyspnea^[Ref]

Genitourinary

Famotidine-Ibuprofen:

Common (1% to 10%): Urinary tract infection

Ibuprofen:

Common (1% to 10%): Urinary tract infection^[Ref]

Psychiatric

Ibuprofen:

Postmarketing reports: Depression, anxiety^[Ref]