Note: This document contains side effect information about pralatrexate. Some dosage forms listed on this page may not apply to the brand name Folotyn.
Applies to pralatrexate: intravenous solution.
Serious side effects of Folotyn
Along with its needed effects, pralatrexate (the active ingredient contained in Folotyn) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking pralatrexate:
More common
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- body aches or pain
- chills
- convulsions
- cough
- cracked lips
- decreased urine
- diarrhea
- difficult or labored breathing
- difficulty with swallowing
- dry mouth
- ear congestion
- fast, pounding, or irregular heartbeat or pulse
- fever
- headache
- increased thirst
- loss of appetite
- loss of voice
- lower back or side pain
- mood changes
- muscle pain or cramps
- nasal congestion
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- runny nose
- shortness of breath
- sneezing
- sore throat
- sores, ulcers, or white spots on the lips, tongue, or inside the mouth
- swelling
- tightness in the chest
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
Other side effects of Folotyn
Some side effects of pralatrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Abdominal or stomach pain
- back pain
- bloody nose
- constipation
- itching skin
- lack or loss of strength
- night sweats
- pain in the arms or legs
- rash
- weight loss
For Healthcare Professionals
Applies to pralatrexate: intravenous solution.
Gastrointestinal
Very common (10% or more): Mucositis (70%), nausea (40%), constipation (33%), vomiting (25%), diarrhea (21%), anorexia (15%)[Ref]
Hematologic
Very common (10% or more): Thrombocytopenia (41%), anemia (34%), neutropenia (24%), leukopenia (11%)
Common (1% to 10%): Febrile neutropenia, pancytopenia[Ref]
General
The most common side effects observed in patients with peripheral T-cell lymphoma (PTCL) were mucositis, thrombocytopenia, nausea, and fatigue.[Ref]
Cardiovascular
Very common (10% or more): Edema (30%), tachycardia (10%)
Uncommon (0.1% to 1%): Cardiopulmonary arrest[Ref]
Respiratory
Very common (10% or more): Cough (28%), epistaxis (26%), dyspnea (19%), upper respiratory tract infection (10%)
Metabolic
Very common (10% or more): Hypokalemia (15%)
Common (1% to 10%): Dehydration
Dermatologic
Very common (10% or more): Rash (15%), pruritus (14%)
Frequency not reported: Skin exfoliation, ulceration, toxic epidermal necrolysis
Other
Very common (10% or more): Fatigue (36%), pyrexia (32%), pharyngolaryngeal pain (14%), abdominal pain (12%), pain in extremity (12%), back pain (11%), night sweats (11%), asthenia (10%)
Hepatic
Very common (10% or more): Abnormal liver function tests (13%)
Immunologic
Common (1% to 10%): Sepsis
