Summary

More frequently reported side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.

Applies to levoleucovorin: parenteral injection, parenteral powder for injection.

Side effects include:

Levoleucovorin rescue following high-dose methotrexate: Vomiting, stomatitis, nausea.

Levoleucovorin in combination with fluorouracil: Diarrhea, nausea, stomatitis, vomiting, asthenia/fatigue/malaise, anorexia/decreased appetite, dermatitis, alopecia.

For Healthcare Professionals

Applies to levoleucovorin: intravenous powder for injection, intravenous solution.

Gastrointestinal

Very common (10% or more): Stomatitis (37.5%), vomiting (37.5%), nausea (18.8%)

Common (1% to 10%): Diarrhea, dyspepsia, typhlitis^[Ref]

Respiratory

Common (1% to 10%): Dyspnea^[Ref]

Dermatologic

Common (1% to 10%): Dermatitis

Postmarketing reports: Pruritus, rash^[Ref]

Other

Postmarketing reports: Temperature change, rigors^[Ref]

Nervous system

Common (1% to 10%): Neuropathy, taste perversion^[Ref]

Renal

Common (1% to 10%): Renal function abnormal^[Ref]

Hypersensitivity

Postmarketing reports: Possible allergic reactions

Hematologic

Frequency not reported: Leukopenia, thrombocytopenia

Psychiatric

Common (1% to 10%): Confusion