Applies to lifitegrast ophthalmic: ophthalmic solution.

Serious side effects

Along with its needed effects, lifitegrast ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lifitegrast ophthalmic:

More common

• Changes in vision
• eye irritation or discomfort

Less common

• Blurred vision
• redness of the white part of the eyes or inside of the eyelids

Other side effects

Some side effects of lifitegrast ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Change in taste
• loss of taste

Less common

• Cough
• discomfort or itching of the eyes
• drainage from the eyes
• fever
• headache
• pain or tenderness around the eyes and cheekbones
• stuffy or runny nose
• tightness of the chest
• troubled breathing
• watering of the eyes

For Healthcare Professionals

Applies to lifitegrast ophthalmic: ophthalmic solution.

General

The most commonly reported side effects included instillation site irritation, dysgeusia, reduced visual acuity, and eye pain.^[Ref]

Ocular

Very common (10% or more): Reduced visual acuity (up to 25%), eye irritation (up to 18%), eye pain (up to 12%)

Common (1% to 10%): Conjunctival hyperemia, eye discharge, eye discomfort, eye pruritus, increased lacrimation^[Ref]

Local

Very common (10% or more): Instillation site irritation (up to 25%), instillation site reactions (up to 12%)

Frequency not reported: Instillation site lacrimation, instillation site pain, instillation site pruritus^[Ref]

Nervous system

Very common (10% or more): Dysgeusia (up to 25%)

Common (1% to 10%): Blurred vision, headache

Frequency not reported: Tension headache^[Ref]

Respiratory

Common (1% to 10%): Sinusitis

Postmarketing reports: Bronchospasm, dyspnea, respiratory distress^[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity

Postmarketing reports: Anaphylactic reaction, angioedema^[Ref]

Immunologic

Postmarketing reports: Allergic conjunctivitis, allergic dermatitis, asthma, pharyngeal edema, type IV hypersensitivity reaction^[Ref]

Gastrointestinal

Postmarketing reports: Swollen tongue^[Ref]