Note: This document contains side effect information about tipiracil / trifluridine. Some dosage forms listed on this page may not apply to the brand name Lonsurf.
Summary
Common side effects of Lonsurf include: infection, anemia, asthenia, diarrhea, fatigue, fever, nausea, neutropenia, thrombocytopenia, vomiting, and decreased appetite. Other side effects include: alopecia, and dysgeusia. Continue reading for a comprehensive list of adverse effects.
Applies to tipiracil / trifluridine: oral tablet.
Serious side effects of Lonsurf
Along with its needed effects, tipiracil/trifluridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tipiracil / trifluridine:
More common
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- chills
- cough
- fever
- hoarseness
- lower back or side pain
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- sore throat
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
Less common
- Bladder pain
- bloody or cloudy urine
- frequent urge to urinate
- headache
- muscle aches
- stuffy or runny nose
Other side effects of Lonsurf
Some side effects of tipiracil / trifluridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Change in taste
- decreased appetite
- diarrhea
- hair loss or thinning of the hair
- lack or loss of strength
- loss of taste
- nausea
- stomach pain
- swelling or inflammation of the mouth
- vomiting
For Healthcare Professionals
Applies to tipiracil / trifluridine: oral tablet.
Hematologic
Very common (10% or more): Anemia (77%), neutropenia (67%), thrombocytopenia (42%)
Common (1% to 10%): Febrile neutropenia[Ref]
Other
Very common (10% or more): Asthenia/fatigue (52%), infections (27%), pyrexia (19%)[Ref]
Gastrointestinal
Very common (10% or more): Nausea (48%), diarrhea (32%), vomiting (28%), abdominal pain (21%)
Common (1% to 10%): Stomatitis (8%)[Ref]
Respiratory
Common (1% to 10%): Nasopharyngitis, pulmonary emboli
Uncommon (0.1% to 1%): Interstitial lung disease[Ref]
Metabolic
Very common (10% or more): Decreased appetite (39%)[Ref]
Cardiovascular
Common (1% to 10%): QTc interval prolongation[Ref]
Nervous system
Common (1% to 10%): Dysgeusia[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infections[Ref]
Dermatologic
Common (1% to 10%): Alopecia[Ref]
