Note: This document contains side effect information about benazepril / hydrochlorothiazide. Some dosage forms listed on this page may not apply to the brand name Lotensin HCT.
Applies to benazepril / hydrochlorothiazide: oral tablet.
Warning
Oral route (Tablet)
Discontinue benazepril hydrochloride/hydrochlorothiazide as soon as possible upon awareness of a pregnancy. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Serious side effects of Lotensin HCT
Along with its needed effects, benazepril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking benazepril / hydrochlorothiazide:
Less common
- Blurred vision
- confusion
- decreased urination
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, slow, or irregular heartbeat
- muscle cramps or pain
- numbness, tingling, pain, or weakness in the hands or feet
- rapid breathing
- seizures
- sunken eyes
- sweating
- thirst
- trembling
- unusual tiredness or weakness
- weakness and heaviness of the legs
- wrinkled skin
Rare
- Black, tarry stools
- bloating
- burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
- chest pain
- chills
- constipation
- cough or hoarseness
- darkened urine
- diarrhea
- dizziness or lightheadedness
- feeling of constant movement of self or surroundings
- fever
- headache
- indigestion
- loss of appetite
- lower back or side pain
- nausea
- painful or difficult urination
- pains in the stomach or side, possibly radiating to the back
- persistent non-healing sore
- pink growth
- reddish patch or irritated area
- sensation of spinning
- shiny bump
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- trouble breathing
- unusual bleeding or bruising
- vomiting
- white, yellow or waxy scar-like area
- yellow eyes or skin
Other side effects of Lotensin HCT
Some side effects of benazepril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Cough
- decreased interest in sexual intercourse
- excessive muscle tone
- feeling of constant movement of self or surroundings
- inability to have or keep an erection
- loss in sexual ability, desire, drive, or performance
- muscle stiffness
- muscle tension or tightness
- sensation of spinning
- sleepiness or unusual drowsiness
Rare
- Blistering, peeling, loosening of the skin
- diarrhea
- hives or welts, itching, skin rash
- increased sensitivity of skin to sunlight
- joint or muscle pain
- pinpoint red or purple spots on the skin
- redness of the skin
- redness or other discoloration of the skin
- red irritated eyes
- red skin lesions, often with a purple center
- severe sunburn
For Healthcare Professionals
Applies to benazepril / hydrochlorothiazide: oral tablet.
General
The most common side effects were dizziness, fatigue, headache, and cough.[Ref]
Nervous system
Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence
Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia
Hydrochlorothiazide:
Postmarketing reports: Lightheadedness, headache, paresthesia[Ref]
Respiratory
Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis
Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration
Benazepril:
Postmarketing reports: Eosinophilic pneumonitis
Hydrochlorothiazide:
Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema[Ref]
Other
Common (1% to 10%): Fatigue, vertigo, flu syndrome
Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills
Hydrochlorothiazide:
Postmarketing reports: Vertigo, weakness, pyrexia, asthenia[Ref]
Genitourinary
Common (1% to 10%): Impotence, urinary frequency
Uncommon (0.1% to 1%): Urinary tract infection[Ref]
Gastrointestinal
Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder
Hydrochlorothiazide:
Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]
Musculoskeletal
Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis
Hydrochlorothiazide:
Postmarketing reports: Muscle spasm[Ref]
Dermatologic
Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia
Benazepril:
Postmarketing reports: Stevens-Johnson syndrome, pemphigus
Hydrochlorothiazide:
Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis[Ref]
Psychiatric
Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams
Hydrochlorothiazide:
Postmarketing reports: Restlessness[Ref]
Cardiovascular
Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia
Hydrochlorothiazide:
Postmarketing reports: Necrotizing angiitis[Ref]
Ocular
Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis
Hydrochlorothiazide:
Postmarketing reports: Transient blurred vision, xanthopsia[Ref]
Metabolic
Uncommon (0.1% to 1%): Anorexia
Hydrochlorothiazide:
Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia[Ref]
Immunologic
Uncommon (0.1% to 1%): Infection
Hydrochlorothiazide:
Postmarketing reports: Anaphylactoid reactions[Ref]
Renal
Frequency not reported: Serum creatinine increased, BUN increased[Ref]
Hematologic
Benazepril:
Postmarketing reports: Hemolytic anemia, thrombocytopenia
Hydrochlorothiazide:
Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia[Ref]
Hepatic
Benazepril:
Postmarketing reports: Pancreatitis
Hydrochlorothiazide:
Postmarketing reports: Intrahepatic cholestatic jaundice[Ref]
Endocrine
Hydrochlorothiazide:
Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia[Ref]
