Note: This document contains side effect information about atovaquone / proguanil. Some dosage forms listed on this page may not apply to the brand name Malarone.
Applies to atovaquone / proguanil: oral tablet.
Serious side effects of Malarone
Along with its needed effects, atovaquone/proguanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking atovaquone / proguanil:
Incidence not known
- Blistering, peeling, loosening of skin
- chills
- convulsions
- difficulty swallowing
- fast heartbeat
- hives or welts
- increased sensitivity of skin to sunlight
- itching, redness or other discoloration of skin
- joint or muscle pain
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
- loss of bladder control
- muscle spasm or jerking of all extremities
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash
- red, irritated eyes
- red skin lesions, often with a purple center
- seeing, hearing, or feeling things that are not there
- severe mental changes
- severe sunburn
- shortness of breath
- skin rash
- sores, ulcers or white spots in mouth or on lips
- sudden loss of consciousness
- tightness in chest
- unusual tiredness or weakness
- wheezing
Other side effects of Malarone
Some side effects of atovaquone / proguanil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Abdominal pain
- back pain
- coughing
- diarrhea
- dreams
- fever
- headache
- itching skin
- lack of or loss of strength
- nausea
- muscle pain
- sore throat
- sores in mouth
- sneezing
- vomiting
Less common
- Acid or sour stomach
- belching
- blurred or loss of vision
- disturbed color perception
- dizziness
- double vision
- flu like symptoms
- halos around lights
- heartburn
- indigestion
- loss of appetite
- night blindness
- overbright appearance of lights
- sleeplessness
- stomach discomfort, upset or pain
- trouble sleeping
- tunnel vision
- unable to sleep
- weight loss
Rare
- Discouragement
- fear
- feeling sad or empty
- irritability
- lack of appetite
- loss of interest or pleasure
- nervousness
- trouble concentrating
For Healthcare Professionals
Applies to atovaquone / proguanil: oral tablet.
General
In general, side effects associated with the use of atovaquone-proguanil have been mild. Side effects are more pronounced and occur more frequently when higher doses are used in the treatment of malaria than with lower prophylactic doses.[Ref]
Dermatologic
Dermatologic side effects have included pruritus (2%). Cutaneous reactions ranging from rash, photosensitivity, and urticaria have been reported during postmarketing experience.[Ref]
Gastrointestinal
Gastrointestinal side effects have included abdominal pain (5% to 17%), nausea (3% to 12%), vomiting (1% to 12%), diarrhea (4% to 8%), mouth ulcers (6%), anorexia (5%), dyspepsia (2%), and gastritis (2%). GI upset has also been reported. Stomatitis has been reported during postmarketing experience.[Ref]
Hepatic
Hepatic side effects have included transient increases in liver function tests. These increases have not required discontinuation of therapy. Rare cases of hepatitis, cholestasis, and a single case of hepatic failure have been reported during postmarketing experience.[Ref]
Musculoskeletal
Musculoskeletal side effects have included asthenia (8%), myalgia (7%), and back pain (4%).[Ref]
Nervous system
Nervous system side effects have included headache (4% to 17%), dizziness (2% to 5%), vertigo (2%), and visual disturbances (2%). Rare cases of seizures and psychotic events (such as hallucinations) have been reported during postmarketing experience. However, a causal relationship has not been established.[Ref]
Respiratory
Respiratory side effects have rarely included cough (4%).[Ref]
Hypersensitivity
Hypersensitivity side effects have included rare cases of anaphylaxis. Rare cases of erythema multiforme, Stevens-Johnson syndrome, vasculitis, and angioedema have been reported during postmarketing experience.[Ref]
Psychiatric
Psychiatric side effects including strange or vivid dreams (7%), insomnia (3%), anxiety (less than 1%), and depression (less than 1%) have been reported.[Ref]
Hematologic
Hematologic side effects including neutropenia, anemia (rarely), and pancytopenia in patients with severe renal impairment treated with proguanil have been reported during the postmarketing experience.
Other
Other side effects have included flu-like symptoms (4%) and fever (3%).[Ref]
