While there’s no known interaction between ibuprofen and Mavyret, ibuprofen may not be suitable if you have hepatitis C virus (HCV) infection. If you are taking Mavyret, check with your doctor before taking ibuprofen.

Mavyret is a medication used to treat HCV infection genotypes 1 to 6 in people without cirrhosis or with compensated cirrhosis. It comes in the forms of a tablet and oral pallets and is taken daily with food for 8-16 weeks. Ibuprofen (Advil, Motrin IB) is a popular over-the-counter anti-inflammatory drug (NSAID) used to treat pain and inflammation.

HCV slowly damages the liver and ibuprofen can also adversely affect the liver, causing liver enzymes to become elevated and in rare cases severe liver reactions and liver failure. In some cases the combination of ibuprofen and chronic hepatitis C has been reported to lead to drug-induced liver injury or damage (hepatotoxicity).