By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Medical Answers > How effective is Paxlovid for COVID-19?

How effective is Paxlovid for COVID-19?

Answers by TheMediTary.Com - Last updated: 13-Jul-2023
  • Final data of a study (ERIC-HR Phase 2/3 ) shows when Paxlovid is taken within 3 days of COVID-19 symptom onset, it successfully decreases the risk of being hospitalized by 89% for patients that are at high risk of COVID-19 progressing to severe illness. When taken within 5 days of symptom onset, Paxlovid reduces the risk of being hospitalized by 88%.
  • Paxlovid contains two co-packaged medicines nirmatrelvir (previously known as PF-07321332) and ritonavir.
  • Paxlovid contains oral tablets that are best taken at the first sign of symptoms, after a positive Sars-CoV-2 test. It is taken to help decrease the number and severity of symptoms or avoid severe illness which may lead to hospitalization or death.
  • On December 22, 2021 the FDA issued an Emergency Use Authorization (EUA) for Paxlovid to be used for treatment of mild-to-moderate COVID-19, in patients who have increased risk of hospitalization or death. Patients must be 12 years or older and weigh at least 40kg (88lb), and have a positive Sars-CoV-2 viral test (the virus that causes COVID-19).

How does Paxlovid work?

  • Paxlovid contains co-packaged nirmatrelvir tablets and ritonavir tablets that are taken orally at the first sign of COVID-19 illness, after a positive Sars-CoV-2 viral test.
  • Nirmatrelvir works by blocking an enzyme (called SARS-CoV-2-3CL protease) that the coronavirus needs to replicate.
  • As the virus can not reproduce itself this reduces the severity of symptoms and so decreases the number of hospitalizations and deaths in high risk patients.
  • Ritonavir is an HIV medication that slows the metabolism of nirmatrelvir which helps nirmatrelvir stay in the body longer and a higher concentration, making it more effective.

How do you take Paxlovid?

Paxlovid is prescribed as medicine to be taken at home, for high-risk patients to avoid severe COVID-19 illness, including hospitalization and death. Paxlovid will be one box containing a full five day treatment course with oral nirmatrelvir tablets and ritonavir tablets.

  • Paxlovid should be started as soon as possible after a positive Sars-CoV-2 viral test and within 5 days of the first symptoms.
  • Nirmatrelvir 300mg (two 150mg tablets) taken twice daily for five days.
  • Ritonavir 100mg taken twice daily for five days.

When will it be available?

Paxlovid was issued an Emergency Use Authorization by the FDA on December 22, 2021. Pfizer is expected to start delivery immediately, as it has a supply agreement with the U.S. government that was announced in November 2021.

Does Paxlovid treat Omicron?

  • The Omicron variant of COVID-19 was first detected in mid November 2021.
  • Recent information from Pfizer indicated that Paxlovid will retain robust antiviral activity against the Omicron variant, as in vitro data confirmed that Paxlovid is a potent inhibitor of the Omicron 3CL protease
  • Additional studies the Omicron variant are also underway.

Clinical Trials for Paxlovid.

Patients at HIGH RISK of hospitalization with COVID-19

Paxlovid has an EUA for treating mild to moderate COVID-19, in patients at high risk of severe COVID-19.

Final results from Phase 2/3 ERIC-HR study of the antiviral pill Paxlovid shows it successfully decreases the risk of being hospitalized by 89% for patients that are at high risk of COVID-19 progressing to severe illness. Paxlovid or placebo was taken within 3 days of first COVID-19 symptoms and the results were:

  • 0.7% (5 out of 697) of the Paxlovid patients were hospitalized with no deaths.
  • 6.5% (44 out of 682) of the placebo patients were hospitalized with 9 deaths.
  • Paxlovid patients also had a 10-fold decrease in viral load compared to the placebo group.

Patients at STANDARD RISK of hospitalization with COVID-19

Paxlovid is NOT authorised for COVID-19 patients who have standard risk of hospitalization with COVID-19

Early results from a trial (Phase 2/3 EPIC-SR) looking at Paxlovid use in Covid-19 patients at standard risk of hospitalization, showed a 70% reduction in hospitalization in the Paxlovid patients compared to placebo.

  • 0.7% (3 out of 428) of the Paxlovid patients were hospitalized with no deaths.
  • 2.4% (10 out of 426) of the placebo patients were hospitalized with no deaths.
  • Paxlovid patients also had a 10-fold decrease in viral load compared to the placebo group, which was the same as Phase 2/3 ERIC-HR study.

Can Paxlovid prevent COVID-19?

Post-Exposure Prophylaxis of COVID-19 using Paxlovid

Paxlovid is NOT authorized to be used to prevent COVID-19.

There is an ongoing study (Phase 2/3 EPIC-PEP) looking at how well Paxlovid works at preventing COVID-19 in patients who have been exposed to COVID-19 by a household member. This is an on-going study on COVID-19 post-exposure prophylaxis and results are not yet available.

Click here for more information on: Paxlovid: Uses, Doses, Side Effects and Interactions.

Bottom Line:

  • Paxlovid (nirmatrelvir and ritonavir tablets) has been issued an Emergency Use Authorization for treatment of mild-to-moderate COVID-19 in patients who are at high risk for progression to severe COVID-19, to help reduce the severity of COVID-19 symptoms and also decrease the number of hospitalizations and deaths.
Share this Article

Featured questions

  • Paxlovid side effects: 8 key things to know
  • Alcohol consumption and Paxlovid?
  • Can I drink alcohol after my last dose of Paxlovid?
  • Paxlovid side-effects blood pressure?
  • How long does Paxlovid stay in your system after you take your last dose on day 5?
  • Tamsulosin, Paxlovid taking them together?
  • Can you take Paxlovid twice if COVID rebounds?
  • Can you stop Paxlovid after 5 doses? The side effects are terrible.
  • Paxlovid - Does this drug cause sweating profusely?
  • How fast does Paxlovid work?
  • Paxlovid - Does it create a change in taste?
  • Does Paxlovid interact with Advil?
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch (Hydrocortisone topical)
Centrum Adult (Multivitamins and minerals)
Crovalimab
Cyltezo Prefilled Syringe (Adalimumab)
Zepbound Pen (Tirzepatide)
Mylanta One (Calcium carbonate, magnesium hydroxide, and simethicone)
Uretron Ds (Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate)
Medihoney Wound And Burn Dressing (Topical emollients)
Lidotrode
Libervant (Diazepam (buccal))
Moderna Covid-19 (Covid-19 (6m-11y) vaccine, moderna (2024-2025))
Beqvez (Fidanacogene elaparvovec)
Beqvez (Fidanacogene elaparvovec)
Beqvez (Fidanacogene elaparvovec)

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by