Xgeva is meant to be taken long-term. However, Xgeva should be discontinued if you experience intolerable side effects or serious side effects such as osteonecrosis of the jaw or osteomyelitis, or if Xgeva appears to be ineffective for you.

There have been reports of a higher risk of multiple vertebral fractures and hypercalcemia (high calcium levels) occurring within the first year following discontinuation of Xgeva. Patients should be monitored for both conditions when Xgeva is stopped.

Common side effects reported with Xgeva are bone and joint pain, diarrhea, headache, low phosphate levels, nausea, shortness of breath, and tiredness. Common serious adverse reactions include osteonecrosis of the jaw and osteomyelitis. Always tell your doctor if you experience any new or unusual thigh, hip or groin pain; bone, joint, or muscle pain; or jaw pain.