Answers by TheMediTary.Com - Last updated: 13-Jul-2023
What are the biosimilars of Herceptin?
Herceptin (trastuzumab) is the original brand of trastuzumab, a biological medicine used to treat specific types of breast and gastric cancer, in specific patients and used in conjunction with prescribed treatment regimes.
What is the difference between generic and biosimilar medicines?
- A biosimilar medicine is a copy of the original brand of biological medicine eg Ogivri is biosimilar of Herceptin.
- A generic medicine is a copy of the original brand of small molecule drug eg Wal-Itin is a generic of Claritin.
The biosimilars of Herceptin are:
- Herzuma
- Kanjinti
- Ogivri
- Ontruzant
- Trazimera
Table comparing Herceptin to its Biosimilars
| Brand name | Herceptin | Herzuma | Kanjinti | Ogivri | Ontruzant | Trazimera |
| Active ingredient name | trastuzumab | trastuzumab-pkrb | trastuzumab-anns | trastuzumab-dkst | trastuzumab-dttb | trastuzumab-qyyp |
| Company | Genentech | Celltrion |
Allergan Amgen |
Mylan | Samsung Bioepis | Pfizer |
| Approval date (FDA) | 25 September 1998 | 14 December 2018 | 13 June 2019 | 1 December 2017 | 18 January 2019 | 11March 2019 |
| Interchangeable? | No | No | No | No | No | No |
| Treatment* |
Adjuvant breast cancer, Metastatic breast cancer, Metastatic gastric cancer |
Adjuvant breast cancer, Metastatic breast cancer, Metastatic gastric cancer |
Adjuvant breast cancer, Metastatic breast cancer, Metastatic gastric cancer |
Adjuvant breast cancer, Metastatic breast cancer, Metastatic gastric cancer |
Adjuvant breast cancer, Metastatic breast cancer, Metastatic gastric cancer |
Adjuvant breast cancer, Metastatic breast cancer, Metastatic gastric cancer |
| Form |
150mg Single use vial, 420mg Multiple use vial |
150mg Single use vial, 420mg Multiple use vial |
150mg Single use vial, 420mg Multiple use vial |
150mg Single use vial, 420mg Multiple use vial |
150mg Single use vial, 420mg Multiple use vial |
150mg Single use vial, 420mg Multiple use vial |
| Administration route | intravenous infusion | intravenous infusion | intravenous infusion | intravenous infusion | intravenous infusion | intravenous infusion |