Answers by TheMediTary.Com - Last updated: 13-Jul-2023
What is the difference between Herceptin and Herceptin Hylecta?
Herceptin contains one active ingredient, trastuzumab, and is given as an intravenous (IV) infusion slowly into a vein.
Herceptin Hylecta contains two active ingredients, trastuzumab and hyaluronidase-oysk, and is given as a subcutaneous injection, which is an injection that goes under the skin.
Herceptin and Herceptin Hylecta are NOT interchangeable.
Table of differences between Herceptin injection and Herceptin Hylecta
| Herceptin Injection | Herceptin Hylecta | |
| Active ingredient(s) | Trastuzumab | Trastuzumab and hyaluronidase-oysk |
| Treatment* |
Adjuvant Breast Cancer Metastatic Breast Cancer Metastatic Gastric Cancer |
Adjuvant Breast Cancer Metastatic Breast Cancer |
| Are they interchangeable? | No | No |
| Form |
Single use vial powder to be reconstituted with sterile water for injection Multiple use vial powder to be reconstituted with bacteriostatic water for injection |
Single use, ready to use solution for injection |
| Administration route | Intravenous infusion = slow IV into vein | Subcutaneous injection = injected under skin |
| Time for administration | 90 minutes for initial dose which can be reduced to 30 minutes for later doses | Given over 2 to 5 minutes |
| Administered by | Health Care professional | Health Care professional |
| Storage |
Single use vial: Before reconstitution: Store in the refrigerator 2°C to 8° C (36°F to 46°F) Once reconstituted if not used immediately must be stored between 2°C to 8°C (36°F to 46°F) and discarded after 24 hours if not used. Multiple use vial: Before reconstitution: Store in the refrigerator 2°C to 8° C (36°F to 46°F) Once reconstituted solution can be stored between 2°C to 8°C (36°F to 46°F) for up to 28 days after which remaining solution should be destroyed |
Stored in the refrigerator at 2°C to 8°C (36°F to 46°F) until just before use, when it can be at room temperature (20°C to 25°C) for up to 4 hours |