Uses of Amiodarone Injection Solution:

• It is used to treat certain types of abnormal heartbeats.

What do I need to tell my doctor BEFORE I take Amiodarone Injection Solution?

• If you have an allergy to amiodarone, iodine, or any other part of amiodarone injection solution.
• If you are allergic to amiodarone injection solution; any part of amiodarone injection solution; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have any of these health problems: Certain types of abnormal heartbeats called heart block or sick-sinus syndrome, shock caused by heart problems, or slow heartbeat.
• If you have any of these health problems: Low calcium levels, low magnesium levels, or low potassium levels.
• If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
• If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with amiodarone injection solution, like certain drugs that are used for hepatitis C, HIV, or infections. There are many drugs that must not be taken with amiodarone injection solution.
• If you are taking St. John's wort. Do not take St. John's wort with amiodarone injection solution. This medicine may not work as well.
• If you are breast-feeding. Do not breast-feed while you take amiodarone injection solution. You may also need to avoid breast-feeding for some time after your last dose. Talk with your doctor to see if you need to avoid breast-feeding after your last dose.

This is not a list of all drugs or health problems that interact with amiodarone injection solution.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take amiodarone injection solution with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Amiodarone Injection Solution?

• Tell all of your health care providers that you take amiodarone injection solution. This includes your doctors, nurses, pharmacists, and dentists.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Low blood pressure has happened with amiodarone injection solution. Sometimes this has been deadly. Talk with the doctor.
• Check blood pressure and heart rate as the doctor has told you.
• Have your heart and lung function checked. Talk with your doctor.
• Have an eye exam as you have been told by your doctor.
• Slow heartbeat and the need to get a pacemaker have happened when amiodarone was given with sofosbuvir and certain other hepatitis C drugs. Sometimes, this has been deadly. If you also take drugs for hepatitis C, talk with your doctor.
• If you have a defibrillator or pacemaker, talk with your doctor.
• Avoid grapefruit and grapefruit juice.
• If diarrhea or throwing up happens, talk with the doctor. You will need to make sure to avoid dehydration and electrolyte problems.
• A very bad eye problem has rarely happened with amiodarone injection solution. This may lead to a change in eyesight and sometimes loss of eyesight, which may not come back. Talk with the doctor.
• You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
• This medicine stays in your body for weeks or months even after you stop it. Before you start taking other drugs, be sure to tell your doctor and pharmacist that you have taken amiodarone injection solution.
• If you are 65 or older, use amiodarone injection solution with care. You could have more side effects.
• This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking amiodarone injection solution, call your doctor right away.

How is this medicine (Amiodarone Injection Solution) best taken?

Use amiodarone injection solution as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• This medicine is given as a shot into a vein or into a vein nonstop for a period of time.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Signs of lung or breathing problems like shortness of breath or other trouble breathing, cough, or fever.
• Signs of thyroid problems like change in weight; feeling nervous, excitable, restless, or weak; hair thinning; depression; neck swelling; not able to focus; trouble with heat or cold; menstrual changes; shakiness; or sweating.
• Change in balance.
• Shakiness, trouble moving around, or stiffness.
• Blue or gray skin color.
• Sunburn.
• Coughing up blood.
• Chest pain or pressure.
• A burning, numbness, or tingling feeling that is not normal.
• Fast or slow heartbeat.
• An abnormal heartbeat that is new or worse.
• Change in eyesight, eye pain, or very bad eye irritation.
• If bright lights bother your eyes.
• Dizziness or passing out.
• Trouble controlling body movements.
• Muscle weakness.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Any unexplained bruising or bleeding.
• Lowered interest in sex.
• A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Amiodarone Injection Solution?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Constipation.
• Upset stomach or throwing up.
• Feeling tired or weak.
• Not hungry.
• Stomach pain.
• Headache.
• Trouble sleeping.
• Flushing.
• Change in taste.
• Change in sense of smell.
• More saliva.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Amiodarone Injection Solution?

• If you need to store amiodarone injection solution at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about amiodarone injection solution, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.