Note: This document contains side effect information about melphalan flufenamide. Some dosage forms listed on this page may not apply to the brand name Pepaxto.
Applies to melphalan flufenamide: intravenous powder for injection.
Warning
Melphalan flufenamide can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, cough, burning when you urinate).
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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a new or worsening cough;
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pain or burning when you urinate; or
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low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Common side effects may include:
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low blood cell counts;
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nausea, diarrhea;
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tiredness; or
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cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to melphalan flufenamide: intravenous powder for injection.
Hematologic
Very common (10% or more): Decreased platelets (99%), decreased leukocytes (99%), decreased lymphocytes (97%), decreased neutrophils (95%), decreased hemoglobin (84%)
Common (1% to 10%): Febrile neutropenia, hemorrhages[Ref]
Gastrointestinal
Very common (10% or more): Nausea (32%), diarrhea (27%), constipation (15%), vomiting (13%)[Ref]
Respiratory
Very common (10% or more): Pneumonia (13%), respiratory tract infection (24%), cough (17%), dyspnea (11%), dyspnea exertional (10%)
Common (1% to 10%): Respiratory failure[Ref]
General
Very common (10% or more): Fatigue (55%), pyrexia (24%)
Common (1% to 10%): Sepsis, general physical health deterioration[Ref]
Metabolic
Very common (10% or more): Decreased appetite (14%), hypokalemia (14%), hypocalcemia (10%)[Ref]
Renal
Very common (10% or more): Increased creatinine (68%)[Ref]
Hypersensitivity
Common (1% to 10%): Hypersensitivity reaction[Ref]
Musculoskeletal
Very common (10% or more): Bone pain (13%), pain in extremity (13%), back pain (12%), arthralgia (10%)[Ref]
Psychiatric
Very common (10% or more): Insomnia (11%)[Ref]
Nervous system
Very common (10% or more): Headache (13%), dizziness (11%)[Ref]
Dermatologic
Very common (10% or more): Peripheral edema (14%)[Ref]
