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Home > Drugs > Alkylating agents > Pepaxto
Alkylating agents

Pepaxto

https://themeditary.com/drug/pepaxto-2735.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Jul 13, 2023  Additional Content by TheMediTary.Com

Generic name:  melphalan flufenamide

Drug class: Alkylating agents

Dosage form: lyophilized powder for injection

Availability: Discontinued

Pregnancy & Lactation: Risk data available

Brand names: Melphalan flufenamide

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Pepaxto?

Pepaxto is a prescription medicine used in combination with the medicine dexamethasone to treat adults with multiple myeloma who did not respond to or stopped responding to at least four prior medicines including at least one proteasome inhibitor, one immunomodulatory agent and one
CD38-directed antibody.

Pepaxto is not for use to prepare for transplant.

It is not known if this medicine is safe and effective in children.

How should I use Pepaxto

  • Pepaxto is given to you by your healthcare provider into your vein through intravenous (IV) infusion over 30 minutes.
  • Pepaxto is usually given 1 time every 28 days.
  • Your healthcare provider will decide how many treatments you need.
  • Your healthcare provider will do blood tests before and during your treatment to check for side effects.
  • Your healthcare provider may prescribe medicines to help prevent nausea before your infusion and during treatment.
Detailed Pepaxto dosage information
Pepaxto Dosage information (more detail)

Before Taking

Do not receive Pepaxto if you have a history of a severe allergic reaction to melphalan flufenamide or melphalan.

Pepaxto pregnancy and breastfeeding warnings (more detail)

Before receiving Pepaxto

Before receiving Pepaxto, tell your healthcare provider about all of your medical conditions, including if you:

  • have an infection
  • are pregnant or plan to become pregnant. Pepaxto may harm your unborn baby.
    Females who are able to become pregnant:
    • Your healthcare provider will check to see if you are pregnant before you start treatment.
    • You should use an effective method of birth control (contraception) during treatment and for 6 months after the last dose.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.

Males with female partners who are able to become pregnant:

    • You should use an effective method of birth control (contraception) during treatment and for 3 months after the last dose.
    • Talk to your healthcare provider about effective methods of birth control that you can use during this time.
  • are breastfeeding or plan to breastfeed. It is not known if Pepaxto passes into breast milk.
    Do not breastfeed during treatment with and for 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Related/similar drugs

Darzalex, Blenrep, Tecvayli, Carvykti, Revlimid, Velcade, Pomalyst

Pepaxto side effects

Pepaxto may cause serious side effects, including:

  • Low blood cell counts are common with Pepaxto and can be serious. Your healthcare provider will do blood tests as needed to check your blood cell counts during your treatment.
    • Low platelet counts: Tell your healthcare provider right away if you have a bleeding or bruising under the skin.
    • Low red blood cell counts: Tell your healthcare provider if you are feeling weak, tired or you get tired easily, you look pale, or if you feel short of breath.
    • Low white blood cell counts: A low white blood cell count increases the risk of infections.
  • Infections. Pepaxto can cause infections that have led to death. Tell your healthcare provider right away if you develop new or worsening signs or symptoms of infection such as fever, chills, cough, pain, or burning during urination during treatment with Pepaxto.
  • Secondary cancers. New cancers such as myelodysplastic syndromes or acute leukemia have happened in people with multiple myeloma who have received Pepaxto. Your healthcare provider will monitor you for new cancers.

Your healthcare provider may change your dose, stop your treatment for a period of time, or completely stop your treatment if you have certain side effects.

Pepaxto may cause fertility problems in males and females, which may affect your ability to have children. Talk with your healthcare provider if you have concerns about fertility.

The most common side effects include, low blood cell counts, fatigue, nausea, diarrhea, fever, and cold-like symptoms (respiratory tract infection).

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See more: Pepaxto Side Effects

What other drugs will affect Pepaxto?

Other drugs may interact with melphalan flufenamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

More about Pepaxto ( melphalan flufenamide)

Dosage information
Pepaxto Side Effects
During pregnancy
Pepaxto Prescribing Information
Drug images
Side effects
Drug class: Alkylating agents

Related treatment guides

Multiple Myeloma
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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