Note: This document contains side effect information about chlorpheniramine / phenylephrine / pyrilamine. Some dosage forms listed on this page may not apply to the brand name Poly Hist PD (old formulation).
Applies to chlorpheniramine / phenylephrine / pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release.
Warning
You should not use this medicine if you have severe coronary artery disease, diabetes, an overactive thyroid, asthma, pneumonia, or other breathing problems.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Do not give this medication to a child younger than 6 years old. Death can occur from the misuse of cough and cold medicines in very young children.
You should not use antihistamine medication to make a child sleepy.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
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confusion, hallucinations;
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feeling nervous or irritable;
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trouble sleeping;
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little or no urination;
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a seizure (convulsions);
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numbness or tingly feeling;
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a light-headed feeling, like you might pass out;
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pounding heartbeats or fluttering in your chest; or
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increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed.
Side effects may be more likely in older adults.
Common side effects may include:
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nausea, constipation, loss of appetite;
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rash or itching;
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increased sweating;
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dry mouth, nose, or throat;
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blurred vision;
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headache, dizziness; or
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feeling restless or excited (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to chlorpheniramine/phenylephrine/pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release.
Nervous system
Nervous system side effects including drowsiness and sedation have been reported.[Ref]
Gastrointestinal
Gastrointestinal side effects including dryness of the mucous membranes have been reported.[Ref]
