Applies to praziquantel: oral tablet.
Serious side effects of Praziquantel
Along with its needed effects, praziquantel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking praziquantel:
Incidence not known
- Black, tarry stools
- blistering, peeling, or loosening of the skin
- bloody diarrhea
- blurred or loss of vision
- chest pain or discomfort
- chills
- cough
- dark urine
- diarrhea
- difficulty swallowing
- difficulty with moving
- disturbed color perception
- dizziness
- double vision
- fainting
- fast, slow, or irregular heartbeat
- fever
- general feeling of discomfort or illness
- general tiredness and weakness
- halos around lights
- hives, itching, skin rash
- joint pain, stiffness, or swelling
- light-colored stools
- lightheadedness, dizziness, or fainting
- muscle pains, cramps, or stiffness
- nausea
- night blindness
- overbright appearance of lights
- painful or difficult urination
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- redness of the skin
- severe abdominal or stomach pain
- seizures
- sleepiness or unusual drowsiness
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach discomfort with or without nausea
- stomach pain
- sweating
- swelling of the eyelids, face, lips, hands, or feet
- swollen glands
- thickening of bronchial secretions
- tightness in the chest
- tremor
- troubled breathing
- tunnel vision
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal pain
- vomiting
- yellow eyes and skin
Other side effects of Praziquantel
Some side effects of praziquantel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Change in walking and balance
- clumsiness or unsteadiness
- continuing ringing or buzzing or other unexplained noise in the ears
- dizziness or lightheadedness
- feeling of constant movement of self or surroundings
- headache
- hearing loss
- lack or loss of strength
- loss of appetite
- sensation of spinning
- weight loss
For Healthcare Professionals
Applies to praziquantel: compounding powder, oral tablet.
General
Side effects varied according to dose and duration of therapy. Side effects depended on parasite species, extent of infestation, infection duration, and parasite location in the body. Side effects occurred earlier and were more frequent and/or serious in patients with severe infestation.
Often, it was unclear if this drug, an endogenous reaction to parasites dying from the drug, or symptoms of the infestation caused the reported side effects.
Side effects included malaise, headache, dizziness, abdominal discomfort (with or without nausea), pyrexia, and urticaria; generally in order of severity. Such side effects were more frequent and/or serious in patients with heavy worm burden.
Nervous system
Very common (10% or more): Headache, dizziness
Common (1% to 10%): Vertigo, somnolence (including drowsiness)
Very rare (less than 0.01%): Seizures
Frequency not reported: Cerebral inflammatory reaction
Postmarketing reports: Convulsion, somnolence, vertigo, tinnitus, intention tremor[Ref]
The inflammatory reaction produced by antigenic substances released from dying cysts frequently involved increased intracranial pressure, seizures, severe headaches, nausea, and vomiting. In areas where Taenia solium was endemic, these reactions may occur as the result of undiagnosed cysticercosis in patients being treated for other parasitic infections. The duration of the reaction differs among patients. Delayed reactions have been reported.[Ref]
Gastrointestinal
Very common (10% or more): Gastrointestinal and abdominal pains, nausea, vomiting
Common (1% to 10%): Diarrhea
Frequency not reported: Abdominal discomfort (with or without nausea), gagging
Postmarketing reports: Abdominal pain, bloody diarrhea, vomiting[Ref]
A syndrome of severe abdominal pain and bloody diarrhea was reported less often during schistosomiasis therapy.
Gagging and vomiting have been reported due to the bitter taste of the tablets.[Ref]
Other
Very common (10% or more): Fatigue
Common (1% to 10%): Feeling unwell (asthenia, malaise), pyrexia/fever
Frequency not reported: Rise in temperature, transient edema
Postmarketing reports: Asthenia, fatigue, polyserositis, gait disturbance[Ref]
Dermatologic
A 13-year-old male developed Mazzotti reaction after treatment with ivermectin, praziquantel, and albendazole for presumptive schistosomiasis and strongyloidiasis. Six days after receiving standard empiric therapy, he developed epigastric pain, vomiting, and urticaria. This progressed in 4 hours and included fever, general myalgia, and edema of the face, lower extremities, and penis accompanied by urticaria of the arms, legs, and trunk. He was diagnosed with a Mazzotti reaction and treated with methylprednisolone; symptoms subsided within 12 hours.[Ref]
Very common (10% or more): Urticaria
Common (1% to 10%): Rash
Very rare (less than 0.01%): Pruritus
Frequency not reported: Mazzotti-like reaction
Postmarketing reports: Pruritus, rash, Stevens-Johnson syndrome[Ref]
Metabolic
Common (1% to 10%)/Postmarketing reports: Anorexia
Musculoskeletal
Common (1% to 10%)/Postmarketing reports: Myalgia
Frequency not reported: Musculoskeletal aches and fatigue[Ref]
Hepatic
Frequency not reported: Mild increases in liver enzymes
Postmarketing reports: Hepatitis
Cardiovascular
Very rare (less than 0.01%): Unspecified arrhythmias
Postmarketing reports: Arrhythmia (including bradycardia, ectopic rhythms, ventricular fibrillation, atrioventricular blocks)
Hypersensitivity
Postmarketing reports: Allergic reaction, generalized hypersensitivity, anaphylactic reaction
Hematologic
Postmarketing reports: Eosinophilia
Respiratory
Postmarketing reports: Pneumonitis, dyspnea, wheezing
Ocular
Postmarketing reports: Visual disturbance
