Cefprozil has been assigned to pregnancy category B by the FDA. Animal data failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Cefprozil should only be given during human pregnancy when need has been clearly established.

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Cefprozil is excreted into human milk in small amounts (0.3% of a 1 gram dose). Average milk levels were between 0.25 to 3.3 mcg/mL over 24 hours. The American Academy of Pediatrics has classified cefprozil as compatible with breast-feeding. The manufacturer recommends that caution be used when administering cefprozil to nursing women.

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