Note: This document contains side effect information about pneumococcal 20-valent conjugate vaccine. Some dosage forms listed on this page may not apply to the brand name Prevnar 20.
Applies to pneumococcal 20-valent conjugate vaccine: intramuscular suspension.
Serious side effects of Prevnar 20
Along with its needed effects, pneumococcal 20-valent conjugate vaccine (the active ingredient contained in Prevnar 20) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking pneumococcal 20-valent conjugate vaccine:
More common
- Fever
Incidence not known
- Blistering, peeling, or loosening of the skin
- chest tightness
- chills
- cough
- difficulty swallowing
- dizziness
- fast heartbeat
- hives, itching, skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- trouble breathing
- unusual tiredness or weakness
Other side effects of Prevnar 20
Some side effects of pneumococcal 20-valent conjugate vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- difficulty in moving
- headache
- muscle pain or stiffness
- pain in the joints
For Healthcare Professionals
Applies to pneumococcal 20-valent conjugate vaccine: intramuscular suspension.
Dermatologic
Uncommon (0.1% to 1%): Angioedema, rash
Postmarketing reports: Angioneurotic edema, erythema multiforme[Ref]
Gastrointestinal
Uncommon (0.1% to 1%): Diarrhea, nausea, vomiting
General
The most common adverse events were pain at the injection site, muscle pain, fatigue, headache, arthralgia, and injection site swelling.[Ref]
Hematologic
Postmarketing reports: Lymphadenopathy localized to the region of the injection site[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Hypersensitivity reaction
Postmarketing reports: Anaphylactic/anaphylactoid reaction (including shock)[Ref]
Local
Very common (10% or more): Pain at the injection site (72.5% to 81.2% ), injection site swelling (8.8% to 11.6%)
Common (1% to 10%): Injection site redness
Postmarketing reports: Vaccination-site dermatitis, vaccination-site pruritus, vaccination-site urticaria[Ref]
Metabolic
Frequency not reported: Decreased appetite
Musculoskeletal
Very common (10% or more): Muscle pain (49.8% to 66.6%), arthralgia (13.4% to 15.4%)
Frequency not reported: Limitation of arm movement[Ref]
Nervous system
Very common (10% or more): Headache (32.3% to 38.8%)[Ref]
Other
Very common (10% or more): Fatigue (39.3% to 42.7%), use of antipyretic or pain medication (24.5% to 25.7%)
Common (1% to 10%): Fever
Uncommon (0.1% to 1%): Chills[Ref]
Respiratory
Uncommon (0.1% to 1%): Bronchospasm, dyspnea[Ref]
