Note: This document contains side effect information about ripretinib. Some dosage forms listed on this page may not apply to the brand name Qinlock.
Applies to ripretinib: oral tablet.
Serious side effects of Qinlock
Along with its needed effects, ripretinib (the active ingredient contained in Qinlock) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ripretinib:
More common
- Blistering, peeling, loosening of the skin
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- chest tightness
- constipation
- diarrhea
- difficult or labored breathing
- dizziness
- headache
- nausea or vomiting
- nervousness
- pounding in the ears
- rash, redness, swelling, pain, or ulceration of the skin
- scaling of the skin on the hands and feet
- slow or fast heartbeat
- stomach pain
- tingling of the hands or feet
- unusual weight gain or loss
Less common
- Change in size, shape, or color of existing mole
- chest pain or discomfort
- decreased urine output
- dilated neck veins
- irregular breathing
- irregular heartbeat
- mole that leaks fluid or bleeds
- new mole
- pale skin
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
Rare
- Increased sensitivity of the skin to sunlight
- redness or other discoloration of the skin
- severe sunburn
Other side effects of Qinlock
Some side effects of ripretinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Difficulty in moving
- dry or itching skin
- joint pain or swelling
- lack or loss of strength
- loss of appetite
- loss or thinning of the hair
- muscle pains or stiffness
- swelling or inflammation of the mouth
For Healthcare Professionals
Applies to ripretinib: oral tablet.
Hematologic
Very common (10% or more): Neutropenia (42%), thrombocytopenia (40%), increased activated partial thromboplastin time anemia (24%), increased INR (21%), lymphopenia (13%), febrile neutropenia (11%), decreased neutrophil count (10%)[Ref]
Musculoskeletal
Very common (10% or more): Myalgia (32%), arthralgia (18%), muscle spasms (15%)[Ref]
Metabolic
Very common (10% or more): Anorexia (27%), triglycerides increased (26%), phosphate decreased (26%), triglycerides increased (26%), calcium decreased (23%), weight loss (19%), weight loss (19%), sodium decreased (17%)[Ref]
Hepatic
Very common (10% or more): Blood bilirubin increased (21%), ALT increased (12%)[Ref]
Oncologic
Very common (10% or more): New primary cutaneous malignancies (e.g., cutaneous squamous cell carcinoma (cuSCC), keratoacanthoma, melanoma[Ref]
Respiratory
Very common (10% or more): Dyspnea (13%)[Ref]
Other
Very common (10% or more): Fatigue (42%), CPK increased (21%), peripheral edema (17%), asthenia (13%)[Ref]
Nervous system
Very common (10% or more): Headache (19%)[Ref]
Renal
Very common (10% or more): Creatinine increased (16%)[Ref]
Cardiovascular
Very common (10% or more): Hypertension (14%)
Common (1% to 10%): Cardiac dysfunction (e.g., cardiac failure, acute left ventricular failure, diastolic dysfunction, ventricular hypertrophy)[Ref]
Dermatologic
Very common (10% or more): Alopecia (52%), palmar-plantar erythrodysesthesia syndrome (PPES) (21%), dry skin (13%), pruritus (11%)[Ref]
Gastrointestinal
Very common (10% or more): Nausea (39%), abdominal pain (36%), constipation (34%), lipase increased (32%), diarrhea (28%), vomiting (21%), serum amylase increased (13%), stomatitis (11%)[Ref]
