Note: This document contains side effect information about lucinactant. Some dosage forms listed on this page may not apply to the brand name Surfaxin.
Applies to lucinactant: intratracheal suspension.
Serious side effects of Surfaxin
Along with its needed effects, lucinactant (the active ingredient contained in Surfaxin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking lucinactant:
More common
- Bluish lips or skin
- cough
- coughing up blood
- fast heartbeat
- fever or chills
- pale skin
- rapid, shallow breathing
- shortness of breath
- slow heartbeat
- sneezing
- troubled breathing
- wheezing
Incidence not known
- Blue or white in color
- heart may stop
- no oxygen to lungs
- patient unresponsive
Other side effects of Surfaxin
Some side effects of lucinactant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- clay-colored stools
- coma
- convulsions
- dark urine
- decreased urine output
- fruit-like breath odor
- loss of appetite
- rapid, deep breathing
- rash
- restlessness
- sweating
- swelling of the face, ankles, or hands
- unusual bleeding or bruising
- vomiting of blood
- yellow eyes or skin
For Healthcare Professionals
Applies to lucinactant: intratracheal suspension.
Cardiovascular
Very common (10% or more): Patent ductus arteriosus (up to 43%), hypotension (at least 10%), bradycardia (at least 10%)
Common (1% to 10%): Pallor (up to 10%)[Ref]
Gastrointestinal
Very common (10% or more): Necrotizing enterocolitis (up to 17%)[Ref]
Hematologic
Very common (10% or more): Anemia (at least 10%)[Ref]
Hepatic
Very common (10% or more): Jaundice (at least 10%)
Metabolic
Very common (10% or more): Metabolic acidosis (at least 10%), hyperglycemia (at least 10%), hyponatremia (at least 10%)[Ref]
Nervous system
Very common (10% or more): Intraventricular hemorrhage (up to 52%)
Common (1% to 10%): Periventricular leukomalacia (up to 10%)[Ref]
Ocular
Very common (10% or more): Retinopathy of prematurity (up to 32%)[Ref]
Other
Very common (10% or more): Acquired sepsis (up to 45%)
Respiratory
Very common (10% or more): Apnea (up to 66%), endotracheal tube reflux (up to 27%), endotracheal tube obstruction (up to 16%), pulmonary air leak (up to 15%), oxygen desaturation (at least 10%), pneumonia (at least 10%)
Common (1% to 10%): Pulmonary hemorrhage (up to 10%), respiratory acidosis (up to 10%), pulmonary interstitial emphysema (up to 9%), pneumothorax (up to 4%)[Ref]
