Note: This document contains side effect information about trientine. Some dosage forms listed on this page may not apply to the brand name Syprine.
Applies to trientine: oral capsule.
Serious side effects of Syprine
Along with its needed effects, trientine (the active ingredient contained in Syprine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking trientine:
Less common
- Pale skin
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
Incidence not known
- Dark-colored urine
- difficulty in breathing, chewing, talking, or swallowing
- double vision
- drooping eyelids
- fever and chills
- general feeling of discomfort or illness
- headaches
- inability to move the eyes
- increased blinking or spasms of the eyelid
- loss of appetite
- muscle cramps, spasms, or stiffness
- muscle or joint pain
- sore tongue
- sore throat
- sticking out of the tongue
- stomach cramps, pain, or tenderness
- swollen glands
- uncontrolled twisting movements of the neck, trunk, arms, or legs
- unusual facial expressions
Get emergency help immediately if any of the following symptoms of overdose occur while taking trientine:
Symptoms of overdose
- Agitation
- bone pain
- coma
- confusion
- decreased urine output
- dizziness
- headache
- hostility
- irritability
- lethargy
- loss of appetite
- muscle twitching
- nausea
- rapid weight gain
- seizures
- stupor
- swelling of the face, ankles, or hands
- trouble breathing
- unusual tiredness or weakness
- vomiting
Other side effects of Syprine
Some side effects of trientine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Constipation
- diarrhea
- hair loss
- mood changes
For Healthcare Professionals
Applies to trientine: oral capsule, oral tablet.
Nervous system
Frequency not reported: Myasthenia gravis[Ref]
Gastrointestinal
Frequency not reported: Nausea, duodenitis, severe colitis, heartburn, epigastric pain and tenderness, acute gastritis, aphthoid ulcers, abdominal pain, melena[Ref]
Hematologic
Very rare (less than 0.01%): Anemia, hypochromic microcytic anemia[Ref]
Musculoskeletal
Frequency not reported: Systemic lupus erythematosus, dystonia, muscular spasm, cramps, muscle pain, rhabdomyolysis[Ref]
Metabolic
Frequency not reported: Iron deficiency, anorexia[Ref]
Dermatologic
Frequency not reported: Skin rash, thickening/fissuring/flaking of the skin[Ref]
Other
Frequency not reported: Malaise, weakness[Ref]
