Note: This document contains side effect information about tiopronin. Some dosage forms listed on this page may not apply to the brand name Thiola EC.
Applies to tiopronin: oral tablet, oral tablet delayed release.
Serious side effects of Thiola EC
Along with its needed effects, tiopronin (the active ingredient contained in Thiola EC) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tiopronin:
More common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- cloudy urine
- hives, itching, skin rash
- pale skin
- rapid weight gain
- tingling of the hands or feet
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
Incidence not known
- Bloody urine
- blurred vision
- chest pain or tightness
- confusion
- decreased frequency or amount of urine
- dilated neck veins
- dizziness
- dry mouth
- fainting
- headache
- increase in heart rate
- increased thirst
- irregular breathing
- irregular heartbeat
- lightheadedness
- loss of appetite
- lower back or side pain
- nausea
- nervousness
- pounding in the ears
- rapid breathing
- slow or fast heartbeat
- sunken eyes
- vomiting
- wrinkled skin
- yellow skin or eyes
Other side effects of Thiola EC
Some side effects of tiopronin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bruising
- cough
- decreased interest in sexual intercourse
- diarrhea
- difficulty in moving
- fever
- inability to have or keep an erection
- large, flat, blue or purplish patches in the skin
- loss in sexual ability, desire, drive, or performance
- mouth sores
- muscle pain or stiffness
- nausea
- pain in the joints
- skin wrinkling
- stomach pain
Incidence not known
- Arm, back, neck, or leg pain
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- change in or loss of taste
- chapped lips
- dry skin
- excess air or gas in the stomach or bowels
- feeling of constant movement of self or surroundings
- full feeling
- heartburn
- increased sweating
- increased weight
- lack or loss of strength
- passing gas
- sensation of spinning
- stomach discomfort
For Healthcare Professionals
Applies to tiopronin: oral delayed release tablet, oral tablet.
Hepatic
Postmarketing reports: Jaundice, liver transaminitis[Ref]
Hypersensitivity
Frequency not reported: Drug fever, rash, fever, arthralgia, lymphadenopathy[Ref]
Gastrointestinal
Very common (10% or more): Nausea (25%), diarrhea/soft stools (18%), emesis (10%), oral ulcers (12%)
Frequency not reported: Abdominal pain, abdominal discomfort, abdominal distension, abdominal pain, chapped lips, dry mouth, dyspepsia, eructation, flatulence, GI disorder, gastroesophageal reflux disease[Ref]
Metabolic
Common (1% to 10%): Anorexia[Ref]
Dermatologic
Common (1% to 10%): Rash, ecchymosis, pruritus, urticaria, skin wrinkling
Postmarketing reports: Dry skin, hyperhidrosis, pemphigus foliaceus, skin irritation, skin texture abnormal[Ref]
Hematologic
Common (1% to 10%): Anemia[Ref]
Renal
Postmarketing reports: Nephrotic syndrome, renal failure[Ref]
Respiratory
Common (1% to 10%): Cough[Ref]
Nervous system
Postmarketing reports: Vertigo, ageusia, burning sensation, dizziness, dysgeusia, headache, hypoesthesia, asthenia[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (12%)
Postmarketing reports: Back pain, flank pain, joint swelling, limb discomfort, musculoskeletal discomfort, myalgia, neck pain, pain in extremity[Ref]
Other
Very common (10% or more): Fatigue/malaise (14%), weakness (12%)
Common (1% to 10%): Fever, peripheral edema
Frequency not reported: Hypogeusia (probably due to chelation of trace metals by this drug)
Postmarketing reports: Pain, peripheral swelling, pyrexia[Ref]
Genitourinary
Frequency not reported: Proteinuria (including nephrotic syndrome), membranous nephropathy, impotence
Cardiovascular
Common (1% to 10%): Chest pain
Postmarketing reports: Congestive heart failure, chest pain
