Summary
Commonly reported side effects of tolmetin include: nausea. Other side effects include: abdominal pain, asthenia, diarrhea, dizziness, dyspepsia, edema, headache, heartburn, increased blood pressure, myalgia, myasthenia, prolonged bleeding time, vomiting, weight changes, and flatulence. Continue reading for a comprehensive list of adverse effects.
Applies to tolmetin: oral capsule, oral tablet.
Warning
Oral route (Tablet; Capsule)
NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased with duration of use and in patients with cardiovascular disease or risk factors for cardiovascular disease. Tolmetin is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious, sometimes fatal, gastrointestinal adverse events (eg, bleeding, ulceration, and perforation of the stomach or intestines), especially in the elderly. These events can occur at any time during use and without warning.
Serious side effects of Tolmetin
Along with its needed effects, tolmetin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tolmetin:
More common
- Abdominal or stomach pain
- diarrhea
- dizziness
- headache
- nausea
- numbness or tingling in the arms or legs
- swelling
- trouble thinking, speaking, or walking
- vomiting
- weakness
- weight gain
Less common
- Black, tarry stools
- bladder pain
- blood in the vomit
- bloody or cloudy urine
- blurred or loss of vision
- burning feeling in the chest or stomach
- burning, itching, redness, or stinging of the skin
- chest pain
- difficult, burning, or painful urination
- disturbed color perception
- double vision
- frequent urge to urinate
- halos around lights
- indigestion
- lower back or side pain
- night blindness
- overbright appearance of lights
- severe or continuing stomach pain
- stomach upset
- tenderness in the stomach area
- tunnel vision
Rare
- Back or leg pains
- bleeding gums
- blistering, peeling, or loosening of the skin
- chills
- constipation
- cough or hoarseness
- dark urine
- decreased urine output
- difficulty with breathing
- difficulty with swallowing
- dilated neck veins
- extreme fatigue
- fast, irregular heartbeat
- feeling of discomfort
- fever
- general body swelling
- heartburn
- hives or welts
- increased thirst
- inflammation of the joints
- irregular breathing
- joint or muscle pain
- light-colored stools
- loss of appetite
- muscle aches
- nosebleeds
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- severe and continuing nausea
- shortness of breath
- skin rash
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face, fingers, feet, or lower legs
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tightness in the chest
- trouble with breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal pain
- wheezing
- yellow eyes and skin
Other side effects of Tolmetin
Some side effects of tolmetin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- bloated full feeling
- excess air or gas in the stomach or intestines
- lack or loss of strength
- passing gas
- stomach discomfort
- weight loss
Less common
- Continuing ringing or buzzing or other unexplained noise in the ears
- discouragement
- feeling sad or empty
- hearing loss
- irritability
- loss of interest or pleasure
- sleepiness
- tiredness
- trouble with concentrating
- trouble with sleeping
Rare
- Redness, swelling, or soreness of the tongue
- swelling or inflammation of the mouth
For Healthcare Professionals
Applies to tolmetin: oral capsule, oral tablet.
Gastrointestinal
Very common (10% or more): Nausea (11%)
Common (1% to 10%): Dyspepsia, gastrointestinal (GI) distress, abdominal pain, diarrhea, flatulence, vomiting, constipation, gastritis, peptic ulcer
Frequency not reported: GI bleeding, GI perforation, glossitis, stomatitis[Ref]
Hepatic
Frequency not reported: Hepatitis, liver function abnormalities[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness, drowsiness[Ref]
Hematologic
Common (1% to 10%): Hemoglobin decreased, hematocrit decreased
Frequency not reported: Lymphadenopathy, hemolytic anemia, thrombocytopenia, granulocytopenia, agranulocytosis[Ref]
Renal
Common (1% to 10%): BUN increased
Frequency not reported: Renal failure[Ref]
Hypersensitivity
Frequency not reported: Anaphylactoid reactions[Ref]
Dermatologic
Common (1% to 10%): Skin irritation
Frequency not reported: Urticaria, purpura, erythema multiforme, toxic epidermal necrolysis[Ref]
Cardiovascular
Common (1% to 10%): Blood pressure increased
Frequency not reported: Congestive heart failure[Ref]
General
The most frequently reported side effect was nausea.[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection
Frequency not reported: Hematuria, proteinuria, dysuria[Ref]
Immunologic
Frequency not reported: Serum sickness
Ocular
Common (1% to 10%): Visual disturbance
Frequency not reported: Optic neuropathy, retinal/macular changes[Ref]
Other
Common (1% to 10%): Asthenia, chest pain, edema, weight gain, weight loss, tinnitus
Frequency not reported: Fever[Ref]
Psychiatric
Common (1% to 10%): Depression[Ref]
Respiratory
Frequency not reported: Epistaxis[Ref]
