Other names: NDO
Neurogenic Detrusor Overactivity (NDO) is a type of bladder dysfunction that occurs when the spinal cord and bladder are not able to communicate effectively. It most often occurs in patients with neurologic conditions such as transverse myelitis, spina bifida, multiple sclerosis (MS) and spinal cord injuries.
Neurogenic detrusor overactivity is characterized by involuntary contractions of the bladder, which causes increased pressure in the bladder and reduced bladder capacity.
Patients with neurogenic detrusor overactivity experience frequent and unexpected urine leakage. Elevated bladder pressure can also lead to bladder and kidney damage over time.
Treatments for neurogenic detrusor overactivity include medications have been used to reduce detrusor storage pressure, increase bladder capacity, and improve urinary incontinence. The most commonly used medications are antimuscarinics, beta-3 adrenergic agonists, and botulinum neurotoxin.
