Applies to trofinetide: oral solution.

Serious side effects of Trofinetide

Along with its needed effects, trofinetide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trofinetide:

More common

• Anxiety
• decreased appetite
• diarrhea
• seizures
• weight loss

Other side effects of Trofinetide

Some side effects of trofinetide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Fever
• headache
• muscle aches
• sore throat
• stuffy or runny nose
• unusual tiredness or weakness

For Healthcare Professionals

Applies to trofinetide: oral liquid.

General

The most common adverse reactions were diarrhea and vomiting.^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (82%), vomiting (29%)^[Ref]

Metabolic

Common (1% to 10%): Decreased appetite^[Ref]

Nervous system

Common (1% to 10%): Seizure^[Ref]

Other

Common (1% to 10%): Fever^[Ref]

Psychiatric

Common (1% to 10%): Anxiety, fatigue^[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis^[Ref]