Note: This document contains side effect information about vosoritide. Some dosage forms listed on this page may not apply to the brand name Voxzogo.
Applies to vosoritide: subcutaneous powder for solution.
Serious side effects of Voxzogo
Along with its needed effects, vosoritide (the active ingredient contained in Voxzogo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking vosoritide:
More common
- Blurred vision
- chills
- confusion
- cough
- diarrhea
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fever
- general feeling of discomfort or illness
- headache
- joint pain
- loss of appetite
- muscle aches and pains
- nausea
- runny nose
- shivering
- sore throat
- sweating
- trouble sleeping
- unusual tiredness or weakness
- vomiting
Other side effects of Voxzogo
Some side effects of vosoritide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Difficulty in moving
- dry skin
- ear pain
- feeling of constant movement of self or surroundings
- hives, itching, rash, redness, swelling, or warmth at the injection site
- muscle pain or stiffness
- pain in the joints
- sensation of spinning
- stomach pain
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
For Healthcare Professionals
Applies to vosoritide: subcutaneous powder for injection.
General
The most common adverse effects were injection site reactions, vomiting, arthralgia, gastroenteritis and decreased blood pressure.[Ref]
Cardiovascular
Very common (10% or more): Decreased blood pressure (13%)[Ref]
Dermatologic
Common (1% to 10%): Dry skin[Ref]
Gastrointestinal
Very common (10% or more): Vomiting (27%), gastroenteritis (13%), diarrhea (10%)
Common (1% to 10%): Nausea[Ref]
Hypersensitivity
Common (1% to 10%): Seasonal allergy[Ref]
Immunologic
Very common (10% or more): Anti-drug antibodies (35%)[Ref]
Local
Very common (10% or more): Injection site reactions (85%) including injection site erythema (75%), injection site swelling (62%), and injection site urticaria (25%)
Frequency not reported: Injection site pain, injection site bruising, injection site pruritus, injection site hemorrhage, injection site discoloration, injection site induration[Ref]
Metabolic
Common (1% to 10%): Increased alkaline phosphatase[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (15%)[Ref]
Nervous system
Common (1% to 10%): Dizziness (included dizziness, syncope, presyncope, procedural dizziness, vertigo)[Ref]
Other
Common (1% to 10%): Ear pain, fatigue[Ref]
Respiratory
Very common (10% or more): Influenza (10%)[Ref]
