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Home > Drugs > Miscellaneous hormones > Voxzogo
Miscellaneous hormones

Voxzogo

https://themeditary.com/drug/voxzogo-3641.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Jul 14, 2023  Additional Content by TheMediTary.Com

Generic name: vosoritide

Drug class: Miscellaneous hormones

Dosage form: lyophilized powder for injection, for subcutaneous use

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Vosoritide

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Voxzogo?

Voxzogo is a prescription medicine used to increase linear growth in children with achondroplasia who are 5 years of age and older with open bone growth plates (epiphyses).

It is not known if Voxzogo is safe and effective in children with achondroplasia under 5 years of age.

Before giving you child Voxzogo

Before you give your child Voxzogo, tell your child’s healthcare provider about all your child’s medical conditions, including if they:

  • have kidney problems.
  • are pregnant or plan to become pregnant. It is not known if Voxzogo will harm your child’s unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Voxzogo passes into your child’s breast milk. Talk to your child’s healthcare provider about the best way to feed your child’s baby if your child takes Voxzogo.

How should I take Voxzogo

  • See the detailed Instructions for Use that comes with your child's prescription for instructions about the right way to store, prepare, and give Voxzogo injections at home.
  • Voxzogo is given as an injection under the skin (subcutaneous or SC). Inject Voxzogo 1 time every day, at about the same time each day.
  • If your child’s healthcare provider decides a caregiver can give the injections of Voxzogo at home, your child’s caregiver should receive training on the right way to prepare and inject Voxzogo. Do not try to inject Voxzogo until you have been shown the right way by your child’s healthcare provider or nurse.
  • Your child’s healthcare provider will tell you how often you should give Voxzogo. If your child misses a dose of Voxzogo, it can be given within 12 hours of the scheduled time of injection. If more than 12 hours have passed, do not give the missed dose. Give the next daily dose according to your child’s usual schedule.
  • Your child should eat a meal and drink about 8 to 10 ounces of fluid within 1 hour before injection.
  • In case you are not sure when to inject Voxzogo, call your child’s healthcare provider or pharmacist. Do not give Voxzogo more often than as directed by your child’s healthcare provider.
  • Your child’s dose depends on his or her body weight. Your child’s healthcare provider will tell you which strength of Voxzogo to use and how much to give your child.
  • Your child’s healthcare provider will monitor your child’s growth and instruct you on when your child should stop Voxzogo if they determine that your child is no longer able to grow. Stop giving Voxzogo to your child if instructed by your child’s healthcare provider.

Dosing information

Usual Pediatric Dose for Achondroplasia

- Recommended dosage is based on patient’s weight. Administer subcutaneously once daily.

Actual Body Weight Vial Strength for Reconstitution* Dose Injection Volume
10-11 kg 0.4 mg 0.24 mg 0.3 mL
12-16 kg 0.56 mg 0.28 mg 0.35 mL
17-21 kg 0.56 mg 0.32 mg 0.4 mL
22-32 kg 0.56 mg 0.4 mg 0.5 mL
33-43 kg 1.2 mg 0.5 mg 0.25 mL
44-59 kg 1.2 mg 0.6 mg 0.3 mL
60-89 kg 1.2 mg 0.7 mg 0.35 mL
≥90 kg 1.2 mg 0.8 mg 0.4 mL

- Use: to increase linear growth in pediatric patients with achondroplasia who are 5 years of age and older with open epiphyses. 

Detailed Voxzogo dosage information
Voxzogo Dosage information (more detail)

Before Taking

Before you give your child Voxzogo, tell your child’s healthcare provider about all your child’s medical conditions, including if they:

  • have kidney problems.
  • are pregnant or plan to become pregnant. It is not known if Voxzogo will harm your child’s unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Voxzogo passes into your child’s breast milk. Talk to your child’s healthcare provider about the best way to feed your child’s baby if your child takes Voxzogo.

Voxzogo side effects

Voxzogo may cause serious side effects, including:

  • risk of low blood pressure. Voxzogo may temporarily lower blood pressure in some people. To help reduce the risk of low blood pressure and its symptoms (dizziness, feeling tired, or nausea), your child should eat a meal and drink about 8 to 10 ounces of fluid within 1 hour before receiving Voxzogo.

The most common side effects include:

  • injection site reactions (redness, itching, swelling, bruising, rash, hives, pain)
  • vomiting
  • joint pain
  • decreased blood pressure
  • stomach ache

These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Voxzogo Side Effects

What other drugs will affect Voxzogo?

Tell your child’s healthcare provider about all the medicines your child takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines your child takes. Keep a list of them to show your child’s healthcare provider and pharmacist when your child gets a new medicine.

More about Voxzogo (Vosoritide)

Dosage information
Voxzogo Side Effects
During pregnancy
Voxzogo Injection Prescribing Information
Drug images
Side effects
Drug class: Miscellaneous hormones

Related treatment guides

Achondroplasia
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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