Applies to warfarin: oral tablets.
Warning
- Possible major bleeding, sometimes fatal.330 More likely to occur during initiation of therapy and with higher dosages, resulting in a higher INR.330
- Monitor INR regularly.330 Patients at high risk for bleeding may benefit from more frequent INR monitoring, careful dosage adjustment to achieve desired INR, and shorter duration of therapy.330
- Drugs, dietary changes, and other factors affect INR levels achieved with warfarin sodium therapy.330
- Instruct patients about preventative measures to minimize risk of bleeding and to immediately report signs and symptoms of bleeding to clinician.330
Side effects include:
Most common adverse effects: fatal and nonfatal hemorrhage from any tissue or organ.
For Healthcare Professionals
Applies to warfarin: compounding powder, intravenous powder for injection, oral tablet.
General
The most common adverse reactions were fatal and nonfatal hemorrhage from any tissue or organ.[Ref]
Cardiovascular
Frequency not reported: Hemorrhage, purple toes syndrome, infarction, systemic cholesterol microembolization, vasculitis, systemic atheroemboli[Ref]
Nervous system
Frequency not reported: Cerebral hemorrhage, cerebral subdural hematoma, lethargy, headache, dizziness, taste perversion, paresthesia[Ref]
Gastrointestinal
Frequency not reported: Gastrointestinal hemorrhage, rectal hemorrhage, hematemesis, pancreatitis, diarrhea, nausea, vomiting, melena, abdominal pain, cramping, flatulence, bloating[Ref]
Dermatologic
Frequency not reported: Rash, alopecia, purpura, erythematous swollen skin patches, ecchymosis, skin necrosis, dermatitis, bullous eruptions, urticaria, pruritus[Ref]
Musculoskeletal
Frequency not reported: Tissue necrosis, chills[Ref]
Metabolic
Frequency not reported: Calciphylaxis, edema[Ref]
Respiratory
Frequency not reported: Hemothorax, epistaxis, tracheal or tracheobronchial calcification[Ref]
Genitourinary
Frequency not reported: Hematuria[Ref]
Hematologic
Frequency not reported: Unexplained decrease in hematocrit, hemoglobin decreased[Ref]
Hepatic
Frequency not reported: Jaundice, hepatic dysfunction, hepatitis, cholestatic hepatic injury, liver enzymes elevated[Ref]
Immunologic
Frequency not reported: Hypersensitivity, allergic reactions, anaphylactic reactions[Ref]
Other
Frequency not reported: Fever, fatigue, malaise, asthenia, pain, cold intolerance, feeling cold[Ref]
