Note: This document contains side effect information about goserelin. Some dosage forms listed on this page may not apply to the brand name Zoladex.

Summary

Common side effects of Zoladex include: headache, vasodilation, and diaphoresis. Other side effects include: hypertension. Continue reading for a comprehensive list of adverse effects.

Applies to goserelin: sub-q implant.

Side effects include:

Men: Hot flushes (flashes), sexual dysfunction, decreased erections, lower urinary tract symptoms, pain (worsened in the first month).

Women: Hot flushes (flashes), vaginitis, headache, emotional lability, decreased/increased libido, sweating, depression, acne, breast atrophy, breast enlargement.

For Healthcare Professionals

Applies to goserelin: subcutaneous implant.

Genitourinary

Very common (10% or more): Sexual dysfunction (21%), erectile dysfunction (18%), lower urinary tract symptoms (13%), vaginitis, breast atrophy, breast enlargement

Common (1% to 10%): Gynecomastia, incontinence and urinary frequency (after radiotherapy), ureteric obstruction, pelvic pain

Uncommon (0.1% to 1%): Breast tenderness^[Ref]

Psychiatric

Very common (10% or more): Libido decreased, emotional lability

Common (1% to 10%): Mood changes, depression, insomnia

Very rare (less than 0.01%): Psychotic disorder^[Ref]

Dermatologic

Very common (10% or more): Hyperhidrosis, acne, seborrhea

Common (1% to 10%): Rash, pruritus

Frequency not reported: Alopecia^[Ref]

Cardiovascular

Very common (10% or more): Hot flashes (62%)

Common (1% to 10%): Cardiac failure, myocardial infarction, blood pressure abnormal

Frequency not reported: QT prolongation

Postmarketing reports: Deep vein thrombosis, stroke, transient ischemic attack^[Ref]

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Paresthesia, spinal cord compression, dizziness

Postmarketing reports: Convulsions^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (36%), cystitis (16%), rectal bleeding (14%)

Common (1% to 10%): Proctitis, vomiting^[Ref]

Respiratory

Very common (10% or more): Pharyngitis

Common (1% to 10%): Upper respiratory infection, chronic obstructive pulmonary disease^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Drug hypersensitivity

Rare (0.01% to 0.1%): Anaphylactic reaction^[Ref]

Musculoskeletal

Common (1% to 10%): Bone pain, myalgia, leg cramps, hypertonia

Uncommon (0.1% to 1%): Arthralgia

Postmarketing reports: Osteoporosis, decreased bone mineral density and bone fracture in men^[Ref]

Metabolic

Common (1% to 10%): Glucose tolerance impaired, weight increased, anorexia^[Ref]

Hematologic

Common (1% to 10%): Hematuria^[Ref]

Endocrine

Very rare (less than 0.01%): Pituitary hemorrhage/infarction^[Ref]

Oncologic

Very rare (less than 0.01%): Pituitary tumor^[Ref]

Immunologic

Common (1% to 10%): Influenza syndrome^[Ref]

Local

Common (1% to 10%): Injection site reaction

Other

Common (1% to 10%): Lethargy, pain, edema^[Ref]