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Home > Drugs > Antithymocyte globulin (equine) (monograph) > Antithymocyte globulin (equine) (monograph) Side Effects
Drugs

Lymphocyte immune globulin, anti-thy (equine) Side Effects

Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.

Warning

  • Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.b

  • Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.b

Side effects include:

Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).

Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.

For Healthcare Professionals

Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.

Hypersensitivity

Uncommon (0.1% to 1%): Anaphylactic reaction[Ref]

Dermatologic

Very common (10% or more): Rash (26%)

Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper

Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)

Postmarketing reports: Hyperhidrosis[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (17%)

Common (1% to 10%): Chest pain, back pain[Ref]

Gastrointestinal

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Stomatitis

Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain[Ref]

Cardiovascular

Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion

Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)

Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia[Ref]

Respiratory

Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema

Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia

Postmarketing reports: Dyskinesia, Syncope, tremor[Ref]

Local

Common (1% to 10%): Infusion site pain

Postmarketing reports: Infusion site erythema, infusion site swelling[Ref]

Renal

Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis

Postmarketing reports: Kidney rupture, renal failure acute[Ref]

Ocular

Uncommon (0.1% to 1%): Periorbital edema[Ref]

Metabolic

Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria

Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity[Ref]

Hepatic

Common (1% to 10%): Liver function test abnormal[Ref]

Immunologic

Common (1% to 10%): Infection

Uncommon (0.1% to 1%): Serum sickness

Postmarketing reports: Hepatitis viral, localized infection, systemic infection[Ref]

Psychiatric

Uncommon (0.1% to 1%): Agitation

Postmarketing reports: Confusion, disorientation[Ref]

Other

Very common (10% or more): Pyrexia (40%), chills (27%)

Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence

Postmarketing reports: Aplasia, pain[Ref]

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