Cardiovascular disease: Night owls face higher risk, study says

Evan Walker
Evan Walker TheMediTary.Com |
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Late sleepers may have a higher cardiovascular risk but is it all bad news? Image credit: Westend61/Getty Images
  • A new study focuses on the health impacts of being more active in the evening and going to bed later. In other words, a ‘night owl.’
  • Focusing on heart health, the authors conclude that, compared with non-night owls, they have an increased risk of cardiovascular disease.
  • The authors also drill down into the lifestyle factors that drive this increase in risk.

Cardiovascular diseases are still the leading cause of death globally. The size of this issue ensures that research into its causes and treatments continues at pace.

The latest study to investigate the factors involved in heart disease investigated the role of chronotypes.

The researchers compared people who are more active and alert in the evening (night owls) with those who are most active and alert in the mornings (larks) and those who are somewhere in the middle (intermediates).

Over an average of 14 years of follow-up, they found that night owls’ risk of experiencing a heart attack or stroke was 16% higher than those in the intermediate category.

Their findings appear in the Journal of the American Heart Association.

In 2022, the American Heart Association updated its Life’s Simple 7, a list of measures for improving and maintaining heart health. They added “get healthy sleep” and renamed the list Life’s Essential 8.

Life’s Essential 8 are:

  1. eat better
  2. be more active
  3. quit tobacco
  4. get healthy sleep
  5. manage weight
  6. control cholesterol
  7. manage blood sugar
  8. manage blood pressure.

In the new study, the researchers wanted to understand whether there were links between individuals’ chronotypes and risk factors for cardiovascular disease, as measured by Life’s Essential 8.

They theorized that being a night owl may be a “marker for underlying circadian misalignments,” meaning a disrupted daily wake-sleep cycles.

Earlier work has shown that mismatches between the natural light-dark cycle and an individual’s body clock are associated with cardiometabolic issues. This is one of the reasons why shift workers are at an increased risk of heart disease and metabolic problems.

The authors also explain that individuals with misaligned body clocks might experience disruptions in their brain’s reward pathways. This could increase the likelihood of smoking, drinking alcohol in excess, and less healthy food choices.

In addition, previous research has shown that night owls and individuals with misaligned circadian rhythms are more likely to experience mood disorders, such as anxiety and depression. These conditions are also risk factors for cardiovascular disease.

The researchers wanted to test their theory that night owls are more likely to have a poorer heart Health profile (lower Life’s Essential 8 scores), which would increase their cardiovascular risk.

To investigate, they took data from the UK Biobank, a long-term study carried out in the United Kingdom. Their analysis included records from 322,777 adults aged 39–74 without known cardiovascular disease at the start of the study.

Each participant completed questionnaires, and their chronotype was assessed using their answer to the following question: “Do you consider yourself to be? Definitely a ‘morning’ person; More a ‘morning’ than ‘evening’ person; More an ‘evening’ than a ‘morning’ person; Definitely an ‘evening’ person; Do not know; Prefer not to answer.”

The scientists also had access to information that allowed them to score participants on each of Life’s Essential 8 factors out of 100. They also combined the scores from each factor to create a composite score out of 100.

These individuals were then followed up for an average of 14 years, and any cardiovascular events were recorded.

The researchers’ analysis, as predicted, found that individuals who self-reported as night owls were at an increased risk of cardiovascular disease.

Around two-thirds of participants had an intermediate chronotype, and 8% reported a “definitely evening” chronotype. Compared with “intermediates,” those with a “definitely evening” chronotype were younger, had a lower socioeconomic status, and were more likely to be more highly educated.

Being a night owl was also associated with having a lower overall Life’s Essential 8 score. Specifically, compared with intermediates, “night owls had a 79% higher prevalence of an overall poorer [Life’s Essential 8] score.“

In contrast, being a lark was linked to a slightly better Life’s Essential 8 score than intermediates.

When looking at Health outcomes, the scientists found that being a night owl was associated with a 16% greater risk of heart attack or stroke during follow-up, compared with those in the intermediate group.

Medical News Today spoke to Raj Dasgupta, MD chief medical advisor for Sleepopolis, who was not involved in the study, about these findings. Dasgupta put this figure into perspective:

“A 16% higher relative risk is modest at the individual level, but meaningful at the population level. It is similar in size to other lifestyle-associated risk factors we take seriously in preventive care.”

Interestingly, larks had a 5% lower prevalence of poor Life’s Essential 8 scores than intermediates or night owls.

“Overall, these results are not surprising,” Dasgupta told MNT when askedwhether these findings were in line with previous research. “Previous research strongly links delayed sleep phase disorder and general irregular sleep patterns to higher cardiovascular disease risk.”

William Lu, MD, a sleep medicine practitioner and medical director for Dreem Health, a digital sleep clinic, likewise not involved in the study, also told us that: “The unexpected key takeaway isn’t that evening chronotypes face elevated cardiovascular risk, but rather the link between night owls and increased susceptibility to circadian misalignment.”

“This misalignment,” Lu continued, “appears to be the true source of risk, as it encourages less physical activity, greater nicotine exposure, and higher blood pressure.”

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