Applies to degarelix: parenteral powder for injection.

Side effects include:

Injection site reactions (e.g., pain, erythema, swelling, induration, nodule), hot flashes, weight gain, increased transaminase and γ-glutamyltransferase (γ-glutamyltranspeptidase, GGT, GGTP) concentrations, hypertension, back pain, fatigue, chills, arthralgia, constipation, urinary tract infection.

For Healthcare Professionals

Applies to degarelix: subcutaneous powder for injection.

Hepatic

Very common (10% or more): Increased liver transaminases (47%), increased gamma-glutamyltransferase (10%)

Uncommon (0.1% to 1%): Increased bilirubin, increased alkaline phosphatase^[Ref]

Other

Very common (10% or more): Injection site reaction (including pain, erythema, swelling, induration, nodule; 44%), pyrexia (10%), fatigue (10%)

Common (1% to 10%): Chills, asthenia, influenza-like illness^[Ref]

Hematologic

Very common (10% or more): Decreased hematocrit (40%), decreased hemoglobin (15%)

Common (1% to 10%): Anemia

Rare (less than 0.1%): Neutropenic fever^[Ref]

Cardiovascular

Very common (10% or more): Hot flush (26%), QT/QTc interval prolongation (20%)

Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Cardiac arrhythmia (including atrial fibrillation), palpitations, vasovagal reaction (including hypotension)

Rare (less than 0.1%): Myocardial infarction, cardiac failure^[Ref]

Renal

Very common (10% or more): Abnormal BUN (15%)

Common (1% to 10%): Abnormal creatinine level

Uncommon (0.1% to 1%): Renal impairment^[Ref]

Metabolic

Very common (10% or more): Increased weight (11%), decreased weight (10%)

Common (1% to 10%): Abnormal potassium level

Uncommon (0.1% to 1%): Hyperglycemia/diabetes mellitus, increased cholesterol, decreased appetite, blood calcium changes^[Ref]

Immunologic

Very common (10% or more): Antibody formation (10%)^[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis (including night sweats), rash

Uncommon (0.1% to 1%): Urticaria, skin hyperpigmentation, skin nodule, alopecia, pruritus, erythema^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, constipation, diarrhea

Uncommon (0.1% to 1%): Vomiting, abdominal pain, abdominal discomfort, dry mouth^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, gynecomastia, testicular atrophy, erectile dysfunction

Uncommon (0.1% to 1%): Pollakiuria, micturition urgency, dysuria, nocturia, incontinence, testicular pain, breast pain, pelvic pain, genital irritation, ejaculation failure^[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, musculoskeletal pain and discomfort

Uncommon (0.1% to 1%): Osteoporosis/osteopenia, arthralgia, muscular weakness, muscle spasms, joint swelling/stiffness^[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Mental impairment, hypoesthesia^[Ref]

Psychiatric

Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Loss of/decreased libido, depression^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reaction

Postmarketing reports: Anaphylaxis, angioedema^[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision^[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea^[Ref]