Drug Detail:Ecallantide (Ecallantide [ e-kal-an-tide ])
Drug Class: Hereditary angioedema agents
Usual Adult Dose for Hereditary Angioedema
30 mg subcutaneously in three 10 mg injections; may repeat an additional 30 mg within 24 hours if attack persists.
Usual Pediatric Dose for Hereditary Angioedema
12 years and older: 30 mg subcutaneously in three 10 mg injections; may repeat an additional 30 mg within 24 hours if attack persists.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
US BOXED WARNING:
- ANAPHYLAXIS: Anaphylaxis has been reported after administration of this drug. Because of the risk of anaphylaxis, this drug should only be administered by a healthcare professional with appropriate medical support to manage anaphylaxis and hereditary angioedema. Healthcare professionals should be aware of the similarity of symptoms between hypersensitivity reactions and hereditary angioedema and patients should be monitored closely. Do not administer this drug to patients with known clinical hypersensitivity to the active component.
Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- This drug should only be administered by a healthcare professional with appropriate medical support to manage anaphylaxis and hereditary angioedema.
- The manufacturer product information should be consulted.
Storage requirements:
- Protect from light.
- Refrigerate at 2 to 8C (36 to 46F). Vials removed from refrigeration should be stored below 30C (86F) and used within 14 days or returned to refrigeration until use.
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
Monitoring: Monitor patients closely for hypersensitivity reactions.
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