Thaw prior to use

Thaw EVITHROM® in one of the following ways:

• 2°C to 8°C (refrigerator): vials thaw within 1 day; or
• 20°C to 25°C (room temperature): vials thaw within 1 hour; or
• 37°C for 2 ml and 5 ml vials only: vials thaw within 10 minutes. Do not exceed 37°C and do not leave vials at 37°C for longer than 10 minutes.

Once thawed

Remove the flip-off plastic cap from the vial to expose the rubber stopper.

If using EVITHROM® alone: withdraw the thrombin solution from the glass vial with a sterile needle and syringe.

If using EVITHROM® in conjunction with an absorbable gelatin sponge: remove the rubber stopper (by removing the metal pull tab) and transfer thrombin solution into a sterile container large enough to immerse sponge

EVITHROM® alone

• Sponge target surface (do not wipe) or suction free of blood before application.
• Flood the surface with EVITHROM® using a sterile syringe and small gauge needle.
• After treatment, avoid sponging the clot to assure that it remains securely in place.

EVITHROM® in conjunction with absorbable gelatin sponge, USP

• Using aseptic techniques, immerse gelatin sponge of desired shape into the sterile container with the EVITHROM® solution.
• Vigorously knead the sponge with moistened gloved fingers until all air is expelled and it can return to its original size and shape.
• Hold the saturated sponge in place with gauze or cotton pledget using moderate pressure until hemostasis is achieved.

Vials are for single use only. Discard unused contents.