Usual Adult Dose for Hypotension

Perioperative dosing (patients undergoing surgery with neuraxial or general anesthesia):
Initial dose: 50 to 250 mcg by intravenous bolus (most common doses: 50 to 100 mcg)
Maintenance dose: 0.5 to 1.4 mcg/kg/min by intravenous continuous infusion (titrate to blood pressure goal)

Septic or Other Vasodilatory Shock:
0.5 to 6 mcg/kg/min by intravenous continuous infusion (titrate to blood pressure goal)

• No bolus
• Doses over 6 mcg/kg/min do not show significant incremental blood pressure increases.

Usual Adult Dose for Shock

Perioperative dosing (patients undergoing surgery with neuraxial or general anesthesia):
Initial dose: 50 to 250 mcg by intravenous bolus (most common doses: 50 to 100 mcg)
Maintenance dose: 0.5 to 1.4 mcg/kg/min by intravenous continuous infusion (titrate to blood pressure goal)

Septic or Other Vasodilatory Shock:
0.5 to 6 mcg/kg/min by intravenous continuous infusion (titrate to blood pressure goal)

• No bolus
• Doses over 6 mcg/kg/min do not show significant incremental blood pressure increases.

Usual Adult Dose for Nasal Congestion

10 mg orally every 4 hours
Maximum dose: 60 mg per 24 hours

Usual Pediatric Dose for Nasal Congestion

12 years and older: 10 mg orally every 4 hours
Maximum dose: 60 mg per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Liver cirrhosis patients may have decreased response to this drug.

• Consider larger doses in hepatically impaired patients.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to any of the ingredients
• Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.

Dialysis

Hemodialysis: End stage renal disease (ESRD) on hemodialysis may have increased responsiveness to this drug; consider lower doses in these patients.
Peritoneal dialysis: Data not available

Frequently asked questions

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