Drug Detail:Roflumilast (topical) (monograph) (Zoryve)
Drug Class:
Usual Adult Dose for Plaque Psoriasis
Apply topically to the affected areas once a day
Comments:
- Not intended for ophthalmic, oral, or intravaginal use.
Use: Topical treatment of plaque psoriasis
Usual Pediatric Dose for Plaque Psoriasis
12 to less than 18 years: Apply topically to the affected areas once a day
Comments:
- Not intended for ophthalmic, oral, or intravaginal use.
Use: Topical treatment of plaque psoriasis
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Mild liver dysfunction (Child-Pugh A): Data not available
Moderate or severe liver dysfunction (Child-Pugh B or C): Contraindicated
Precautions
CONTRAINDICATIONS:
Moderate to severe liver dysfunction.
Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- After application, patient should rub cream in completely.
- Breastfeeding women should not apply this drug to the nipple and areola to avoid direct infant exposure.
Storage requirements:
- Store at 20C to 25C (68F to 77F). Deviation between 15C and 30C (59F and 86F) is permitted.
Patient advice:
- Wash hands after application, until this drug is indicated for the treatment of hands.
- Breastfeeding women should apply on smallest area of skin for shortest duration possible, to minimize exposure of this drug via breast milk to the breastfed infant.
