Drug Detail:Thrombin alfa (recombinant) (topical) (monograph) (Recothrom)
Drug Class:
Usual Adult Dose for Hemostasis
For topical use only. May be used in conjunction with an absorbable gelatin sponge.
Dose: Depends on area to be treated.
Evithrom: Thaw prior to application.
Recothrom: Reconstitute prior to application.
Usual Pediatric Dose for Hemostasis
For topical use only. May be used in conjunction with an absorbable gelatin sponge.
Dose: Depends on area to be treated.
Evithrom: Thaw prior to application.
Recothrom: Reconstitute prior to application.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
US BOXED WARNING:
- SEVERE BLEEDING AND THROMBOSIS COMPLICATIONS: The bovine-derived formulation can cause fatal bleeding or thrombosis. Thrombosis may result from the development of antibodies against bovine thrombin. Bleeding may result from the development of antibodies against factor V, and these antibodies may cross-react with human factor V and lead to its deficiency. Do not re-expose patients to the bovine-derived formulation if there are known or suspected antibodies to bovine thrombin and/or factor V. Monitor patients for abnormal coagulation laboratory values, bleeding, or thrombosis.
Do not inject.
Dialysis
Data not available
Other Comments
For thrombin topical marketed as Evithrom:
Do not refreeze thrombin topical once it has been thawed. Do not refrigerate thrombin topical once it has reached at room temperature. Discard unused product after 24 hours at room temperature.
