Antidotes
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Vistogard Dosage

Drug Detail:Vistogard (Uridine triacetate [ ure-i-deen-trye-as-e-tate ])

Generic Name: uridine triacetate 951mg in 1g

Dosage Form: oral granules

Drug Class: Antidotes Miscellaneous metabolic agents

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosage

  • Adults: 10 grams (1 packet) orally every 6 hours for 20 doses, without regard to meals.
    Pediatric: 6.2 grams/m2 of body surface area (not to exceed 10 grams per dose) orally every 6 hours for 20 doses, without regard to meals. The VISTOGARD dose to be administered at 6.2 grams/m2 is presented in Table 1. Measure the dose using either a scale accurate to at least 0.1 gram, or a graduated teaspoon accurate to ¼ teaspoon. Discard any unused portion of granules. Do not use granules left in the open packet for subsequent dosing.
    Table 1 VISTOGARD Pediatric Dose Based on Body Surface Area (m2)
    Patient Body Surface Area
    (m2)    		 Table 1 VISTOGARD 6.2 grams/m2/dose*
    Dose in Grams Dose in Graduated Teaspoons
    *
    Dose by body surface area category in this table was rounded to achieve the approximate dose. Each dose is administered every 6 hours for 20 doses.
    †
    May use 1 entire 10 g packet without weighing or measuring. Do not exceed 10 grams/dose.
    0.34 to 0.44 2.1 to 2.7 1
    0.45 to 0.55 2.8 to 3.4 1 ¼
    0.56 to 0.66 3.5 to 4.1 1 ½
    0.67 to 0.77 4.2 to 4.8 1 ¾
    0.78 to 0.88 4.9 to 5.4 2
    0.89 to 0.99 5.5 to 6.1 2 ¼
    1.00 to 1.10 6.2 to 6.8 2 ½
    1.11 to 1.21 6.9 to 7.5 2 ¾
    1.22 to 1.32 7.6 to 8.1 3
    1.33 to 1.43 8.2 to 8.8 3 ¼
    1.44 and above † 10.0 1 full packet †
  • Administer VISTOGARD as soon as possible after an overdose or early-onset toxicity within 96 hours following the end of fluorouracil or capecitabine administration.
  • Administer full course of VISTOGARD (20 doses) as directed.

Preparation and Administration

  • Mix each VISTOGARD dose with 3 to 4 ounces of soft foods such as applesauce, pudding or yogurt and ingest within 30 minutes. Do not chew the VISTOGARD granules. Drink at least 4 ounces of water.
  • If a patient vomits within 2 hours of taking a dose of VISTOGARD, initiate another complete dose as soon as possible after the vomiting episode. Administer the next dose at the regularly scheduled time.
  • If a patient misses a dose at the scheduled time, administer that dose of VISTOGARD as soon as possible. Administer the next dose at the regularly scheduled time.
  • Administer VISTOGARD via a nasogastric tube (NG tube) or gastrostomy tube (G-Tube) when necessary (eg, severe mucositis or coma). Follow the instructions below for each dose administration:
    1. Prepare approximately 4 fluid ounces (about 100 mL) of a food starch-based thickening product in water and stir briskly until the thickener has dissolved.
    2. Crush the contents of one full 10 gram packet of VISTOGARD granules to a fine powder.
    3. Add the crushed VISTOGARD granules to 4 ounces (about 100 mL) of the reconstituted food starch-based thickening product. For pediatric patients receiving less than 10 grams, prepare the mixture at a ratio of no greater than 1 gram per 10 mL of reconstituted food starch-based thickening product and mix thoroughly.
    4. After administration of the mixture using the NG tube or G-Tube, flush the tube with water.
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