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Home > Drugs > Cholinergic muscle stimulants > Amifampridine
Cholinergic muscle stimulants

Amifampridine

https://themeditary.com/drug/amifampridine-7695.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 16, 2023  Additional Content by TheMediTary.Com

Generic name: amifampridine [ am-i-fam-pri-deen ]

Drug class: Cholinergic muscle stimulants

Dosage form: oral tablet (10 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Firdapse

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Amifampridine?

Amifampridine is used to treat Lambert-Eaton myasthenic syndrome in adults.

Amifampridine may also be used for purposes not listed in this medication guide.

Warnings

Amifampridine can cause seizures, even if you have never had a seizure in the past. Stop taking amifampridine and call your doctor right away if you have a seizure.

How should I take Amifampridine

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take amifampridine with or without food.

Do not take more than 2 tablets at one time. Do not take more than 8 tablets in 24 hours.­

The amifampridine tablet may be split in half if needed.

Store at room temperature away from moisture and heat.

Throw away any amifampridine not used before the expiration date on the medicine label.

Dosing information

Usual Adult Dose for Lambert-Eaton Myasthenic Syndrome:

-Initial dose: 15 mg to 30 mg orally once a day in divided doses (3 to 4 times daily)
-Maximum single dose: 20 mg
-Maximum daily dose: 80 mg/day

Comments:
-Dose may be increased by 5 mg daily every 3 or 4 days.
-If a dose is missed, patients should not take double or extra doses.

Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS)

Usual Pediatric Dose for Lambert-Eaton Myasthenic Syndrome:

6 years to less than 17 years weighing less than 45 kg:
-Initial dose: 7.5 mg to 15 mg orally once a day in divided doses (2 to 3 times daily)
-Maximum single dose: 15 mg
-Maximum daily dose: 50 mg

Comments:
-Dose may be increased daily in 2.5 mg to 5 mg increments, divided in up to 5 doses daily.
-Dosage should be increased based on clinical response and tolerability.
-A suspension can be prepared when patients require a dosage in less than 5 mg increments.

6 years to less than 17 years weighing 45 kg or more:
-Initial dose: 15 mg to 30 mg daily in divided doses (2 to 3 times daily)
-Maximum single dose: 30 m
-Maximum daily dose: 100 mg

Comments:
-Dose may be increased daily in 5 mg to 10 mg increments, divided in up to 5 doses daily.
-Dosage should be increased based on clinical response and tolerability.

Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS)

Detailed Amifampridine dosage information
Amifampridine Dosage information (more detail)

Before Taking

You should not use amifampridine if you are allergic to it, or if:

  • you have had a seizure in the past; or

  • you are allergic to dalfampridine.

Tell your doctor if you have ever had:

  • a seizure;

  • liver disease;

  • kidney disease; or

  • if you also take a form of amifampridine obtained from a compounding pharmacy (3,4-diaminopyridine or 3,4-DAP).

Tell your doctor if you are pregnant or breast-feeding.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Amifampridine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Amifampridine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Amifampridine can cause seizures, even if you have never had a seizure in the past.

Stop using amifampridine and call your doctor at once if you have a seizure.

Common side effects of amifampridine may include:

  • tingly feeling in your hands, feet, face, mouth, or other parts of your body;

  • nausea, stomach pain, diarrhea;

  • headache, back pain;

  • increased blood pressure;

  • abnormal liver function tests;

  • muscle spasms; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Amifampridine Side Effects

What other drugs will affect Amifampridine?

Amifampridine can cause seizures, especially if you also use certain medicines for infections, asthma, depression, mental illness, attention deficit disorder, or severe pain.

Many drugs can affect amifampridine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

More about Amifampridine (Amifampridine [ am-i-fam-pri-deen ])

Dosage information
Amifampridine Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Cholinergic muscle stimulants

Related treatment guides

Lambert-Eaton Myasthenic Syndrome
Autoimmune Disorders
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Uses Warnings Before Taking Dosage Side effects Interactions
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