Endari is an amino acid that affects the processes of growth and function of cells in the stomach and intestines.

Endari is a medical food product that is used to supplement dietary sources of glutamine. Endari is used to treat a this medicine deficiency, or a loss of glutamine caused by injury or illness.

Endari is also used in combination with human growth hormone to treat short bowel syndrome.

Endari may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

When treating short bowel syndrome, you may need to take Endari 6 times per day for up to 16 weeks.

The number of times per day you take Endari depends on the reason you are using it. Always follow your doctor's instructions.

Take Endari oral powder with a meal or snack unless directed otherwise.

Take Endari tablets on an empty stomach, at least 1 hour before or 2 hours after a meal.

Dissolve your dose of glutamine oral powder in at least 8 ounces of hot or cold liquid. You may also mix the powder with a soft food such as pudding, applesauce, or yogurt. Stir the mixture and eat or drink all of it right away.

Do not pour dry Endari powder directly into a tube feeding formula. Always mix the powder with water and infuse it directly into the feeding tube using a syringe.

While using Endari, you may need frequent blood or urine tests.

Endari may be only part of a complete program of treatment that may also include a special diet, tube feedings, and IV fluids. It is very important to follow the diet and medication plan created for you by your doctor or nutrition counselor.

Store at room temperature away from moisture and heat. Keep each dose of the oral powder in its packet until you are ready to use the medicine.

To make sure Endari is safe for you, tell your doctor if you have:

• liver disease; or

• kidney disease.

FDA pregnancy category C. It is not known whether Endari will harm an unborn baby. Do not use Endari without a doctor's advice if you are pregnant.

It is not known whether glutamine passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

An overdose of Endari is not expected to produce life-threatening symptoms.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Endari may cause serious side effects. Call your doctor at once if you have:

• chest pain;

• hearing problems; or

• signs of infection such as fever, chills, sore throat, flu symptoms, mouth sores, unusual weakness.

Common side effects of Endari may include:

• nausea, vomiting, stomach pain, gas;

• swelling in your hands or feet;

• muscle or joint pain, back pain;

• headache, dizziness, tired feeling;

• mild skin rash or itching; or

• dry mouth, runny nose, increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.