What is Hepatitis C?

Hepatitis C is a viral infection. It can inflame and damage the liver.

Hepatitis C is usually transmitted through contact with infected blood. It can be spread through:

• Shared needles during intravenous drug use
• Shared devices used to snort cocaine
• Unprotected sexual intercourse (this is uncommon)
• Accidental stick with a contaminated needle
• Blood transfusions (rare because of improved screening techniques since 1992)
• Renal dialysis
• Childbirth, from mother to child during delivery
• Contaminated tattoo or body piercing equipment

The hepatitis C virus can cause short-term (acute) or long-term (chronic) hepatitis C. Most people with acute hepatitis C eventually develop chronic hepatitis C.

Most people with hepatitis C don't know that they are infected. That’s because hepatitis C usually does not cause symptoms.

After having this silent infection for 20 to 30 years, about one-third of people develop cirrhosis. Cirrhosis is a serious liver disease that can lead to death. A smaller group of people with chronic hepatitis C develop liver cancer.

The United States Preventive Services Task Force and Centers for Disease Control and Prevention recommend screening for hepatitis C virus (HCV) infection in people at higher than average risk. Also there is a high prevalence of infection in adults born between 1945 and 1965. If you were born during that time, you should get a one-time simple blood test to make sure you are not infected.

Symptoms

Many people with hepatitis C do not have any symptoms.

Some people develop symptoms that last for up to 3 months. These symptoms include:

• A general sick feeling
• A yellowish discoloration of the skin
• Weakness
• Poor appetite
• Fatigue
• Nausea
• Abdominal pain

Some people with acute hepatitis C completely eliminate the virus from their bodies. They don’t suffer any long-term consequences.

But the majority of people with acute hepatitis C remain infected. They develop chronic hepatitis C.

Only some people with long-term hepatitis C develop symptoms. These symptoms include:

• Weight loss
• Poor appetite
• Fatigue
• Aching joints

Most people with chronic hepatitis C do not have any symptoms for 20 to 30 years. All the while, however, the virus slowly damages their livers. Unless they are tested for hepatitis C, many of these people do not know that they are infected. That is, until they develop the symptoms of advanced liver disease.

Diagnosis

To make a diagnosis, your doctor will ask about symptoms of hepatitis C or advanced liver disease.

He or she will ask about your exposure to risk factors for hepatitis C. These include:

• A history of intravenous drug use
• A history of nasal cocaine use
• Blood transfusions, especially before 1992
• Multiple sexual partners
• Previous or current work in the health care field.
• History of hemodialysis

Your doctor will examine you. He or she will look for evidence of liver disease, such as:

• Enlarged liver or spleen
• Swollen abdomen
• Ankle swelling
• Muscle wasting

Hepatitis C infection is confirmed by certain tests. One test looks for hepatitis C virus in your blood. Another test detects infection-fighting proteins (antibodies). Antibodies to hepatitis C indicate that you have been exposed to the virus.

If you have hepatitis C, blood tests can determine the subtype of virus. Different subtypes respond differently to treatment.

You may need a liver biopsy. In a biopsy, a small piece of liver tissue is removed and examined in a laboratory. The biopsy helps predict whether you will develop complications from liver disease.

Expected Duration

Most people with hepatitis C have the infection for life. Some eventually develop cirrhosis or other forms of severe liver disease.

Prevention

There is no vaccine to protect against hepatitis C. The only way to prevent this disease is to avoid the risk factors.

The most effective ways to prevent hepatitis C:

• Don't inject illegal drugs.
• Don't snort cocaine.
• Make sure body piercing or tattooing is done using clean equipment.
• If you are a health care worker, follow standard infection control precautions.
• Avoid unprotected sexual intercourse unless you are in a long-term relationship with one person.

It is rare for someone in a monogamous, long-term relationship with an infected partner to become infected. Discuss your need for precautions with your doctor.

Drinking alcohol makes hepatitis C worse. If you have hepatitis C, avoid alcohol.

Treatment

Not everyone infected with hepatitis C needs treatment. Discuss the potential benefits and side effects of treatment with your doctor.

The first treatment used for hepatitis C was a combination of alpha interferon and ribavirin (Virazole). Side effects from these drugs are very common. And many people don’t tolerate the therapy, especially the interferon.

Treatment today has changed dramatically. Antiviral drugs are much more effective at clearing the hepatitis C virus from the body and allowing the liver to heal. They also have fewer and less severe side effects compared to interferon.

There are six different hepatitis C genotypes. The choice of antiviral medication depends upon which one is causing your infection. In the United States, the most common subtype is genotype 1.

The treatment goal is to totally clear your blood of any detectable virus using a blood test called HCV RNA. If you have no detectable HCV RNA 12 weeks or more after you have completed antiviral therapy, the cure rate is close to 100 percent.

Your doctor will recommend hepatitis A and B vaccinations. He or she will also advise against drinking any alcohol. These actions will reduce the chance that you will have further liver damage.

Treatment options

The following list of medications are in some way related to or used in the treatment of this condition.

• Harvoni
• Sovaldi
• Epclusa
• Vosevi
• Intron A

View more treatment options

When To Call a Professional

Call your doctor if you have symptoms of hepatitis C. Also call if you may have been exposed to the virus.

The Centers for Disease Control and Prevention recommends that anyone born between 1945 and 1965 consider getting a one-time blood test for hepatitis C.

High-risk individuals should be tested for hepatitis C. High-risk individuals include anyone who:

• Received transfusions of blood or blood products before 1992
• Received an organ transplant before 1992
• Has ever injected drugs or snorted cocaine
• Has been on long-term hemodialysis
• Has had multiple sexual partners
• Has a long-term sexual partner with hepatitis C
• Lives in the same household as someone with hepatitis C
• Has evidence of liver disease

Prognosis

Most people infected with hepatitis C virus eventually develop chronic hepatitis C.

Long-term complications often do not develop until after decades of infection. At that time, some people develop cirrhosis. A smaller group of people develop liver cancer.

Anti-viral therapy can cure the condition and substantially decrease the risk of long-term complications.

Additional Info

American Liver Foundation
http://www.liverfoundation.org

Centers for Disease Control and Prevention
https://www.cdc.gov/