By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Antidotes > Methylene blue (injection) > Methylene blue (injection) Side Effects
Antidotes

Methylene blue Side Effects

Applies to methylene blue: intravenous solution.

Warning

Intravenous route (Solution)

Methylene blue may cause serious or fatal serotonergic syndrome when used in combination with serotonergic drugs. Avoid concomitant use of methylene blue with selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors.

Serious side effects of Methylene blue

Along with its needed effects, methylene blue may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking methylene blue:

Incidence not known

  • Agitation
  • bluish-colored lips, fingernails, or palms
  • confusion
  • cough
  • dark urine
  • diarrhea
  • difficulty breathing
  • difficulty swallowing
  • dizziness or lightheadedness
  • fast heartbeat
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • overactive reflexes
  • pale skin
  • poor coordination
  • rapid heart rate
  • redness of the skin
  • restlessness
  • shivering
  • sore throat
  • sweating
  • talking or acting with excitement you cannot control
  • tightness in the chest
  • trembling or shaking
  • twitching
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking methylene blue:

Symptoms of overdose

  • Abdominal or stomach pain
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • blue staining of the urine, skin, and mucous membranes
  • bluish-colored lips, fingernails, or palms
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dark urine
  • difficulty breathing
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fear
  • fever
  • headache
  • increased sensitivity of the eyes to light
  • nausea
  • pale skin
  • rapid heart rate
  • rapid shallow breathing
  • shakiness in the legs, arms, hands, or feet
  • sore throat
  • tightness in the chest
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Other side effects of Methylene blue

Some side effects of methylene blue may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • changes in skin color
  • feeling hot or cold
  • increased sweating
  • loss of taste
  • muscle or joint pain
  • pain at the infusion site
  • pain in the arms or legs

Less common

  • Back pain
  • bruising
  • chills
  • general feeling of discomfort or illness
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle aches and pains
  • muscle spasm
  • runny nose
  • trouble sleeping

For Healthcare Professionals

Applies to methylene blue: compounding powder, injectable solution, intravenous solution, oral tablet.

Cardiovascular

Common (1% to 10%): Chest pain, chest discomfort, presyncope, syncope

Frequency not reported: Cardiac arrhythmia, tachycardia, hypertension, hypotension, palpitations[Ref]

Hematologic

Common (1% to 10%): Ecchymosis

Frequency not reported: Hemolytic anemia, hemolysis, methemoglobinemia, hemoglobin decreased, hyperbilirubinemia (in infants only)[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]

Immunologic

Common (1% to 10%): Influenza-like illness[Ref]

Local

Common (1% to 10%): Injection site pain, injection site discomfort

Frequency not reported: Infusion site extravasation, infusion site induration, infusion site pruritus, infusion site swelling, infusion site urticaria, peripheral swelling[Ref]

Musculoskeletal

Very common (10% or more): Pain in extremity (84%)

Common (1% to 10%): Musculoskeletal pain, back pain, muscle spasms, chills, arthralgia

Frequency not reported: Serotonin syndrome, myalgia[Ref]

Ocular

Frequency not reported: Mydriasis, eye pruritus, ocular hyperemia, vision blurred[Ref]

Metabolic

Common (1% to 10%): Decreased appetite, limb discomfort

Frequency not reported: Local tissue necrosis at the injection site[Ref]

Psychiatric

Common (1% to 10%): Anxiety

Frequency not reported: Confusional state, agitation[Ref]

Genitourinary

Very common (10% or more): Chromaturia (blue-green) (74%)

Frequency not reported: Dysuria[Ref]

Hepatic

Frequency not reported: Elevated liver enzymes[Ref]

Respiratory

Common (1% to 10%): Dyspnea

Frequency not reported: Dyspnea, tachypnea, hypoxia, nasal congestion, rhinorrhea, sneezing[Ref]

Other

Very common (10% or more): Feeling hot (17%), fever

Common (1% to 10%): Feeling cold, discomfort, catheter site pain

Frequency not reported: Genotoxicity, fever, lack of effectiveness, interference with in-vivo monitoring devices, interference with laboratory tests[Ref]

Nervous system

Very common (10% or more): Dysgeusia (20%), dizziness (16%), headache (10%), paresthesia

Common (1% to 10%): Headache, paresthesia oral, dizziness postural

Frequency not reported: Serotonin syndrome (with concomitant use of serotonergic drugs), tremor, aphasia, tremor, aphasia[Ref]

Dermatologic

Very common (10% or more): Skin discoloration (blue) (13%), hyperhidrosis (13%), sweating

Common (1% to 10%): Pallor, contact dermatitis, pruritus, cold sweat, erythema

Frequency not reported: Urticaria, necrotic ulcer, papule, phototoxicity, rash (blue macules, severe burning pain)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (13%)

Common (1% to 10%): Vomiting, abdominal pain, diarrhea, hypoesthesia oral, oral discomfort

Frequency not reported: Feces discoloration (blue-green), dry mouth, flatulence, glossodynia, tongue eruption, thirst, oropharyngeal pain, blue colored saliva[Ref]

Share this Article
Latest News
Medical News

Obesity, unhealthy lifestyles may cause heart to age by 5–45 years

May 08, 2025
Aging: As little as 5 minutes of exercise may keep the brain healthy
Prostate cancer: Simple urine test may help with early detection
Cancer treatment side effects: Exercise may reduce pain, fatigue
Alzheimer's: Exercising in middle age may reduce beta-amyloid in brain...
Heart disease: Just 3 minutes of 'incidental activity' may lower...
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by