Uses of Amphotericin B:

• It is used to treat fungal infections.

What do I need to tell my doctor BEFORE I take Amphotericin B?

• If you have an allergy to amphotericin or any other part of amphotericin B (conventional).
• If you are allergic to amphotericin B (conventional); any part of amphotericin B (conventional); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you are receiving a transfusion of a certain kind of white blood cell (leukocyte).
• If you are breast-feeding. Do not breast-feed while you take amphotericin B (conventional).

This is not a list of all drugs or health problems that interact with amphotericin B (conventional).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take amphotericin B (conventional) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Amphotericin B?

• Tell all of your health care providers that you take amphotericin B (conventional). This includes your doctors, nurses, pharmacists, and dentists.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Some people have had side effects within a few hours of the start of the infusion. Tell your doctor if you have any bad effects during this time.
• Other drugs may be given to help with infusion side effects.
• Very bad kidney problems have happened with amphotericin B (conventional). Most of the time, kidney problems have gotten better after amphotericin B (conventional) was stopped but sometimes they have not gone away. Talk with your doctor.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using amphotericin B (conventional) while you are pregnant.

How is this medicine (Amphotericin B) best taken?

Use amphotericin B (conventional) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as an infusion into a vein over a period of time.
• Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
• Fever or chills.
• Very bad dizziness or passing out.
• Very upset stomach or throwing up.
• Fast breathing.
• Feeling very tired or weak.
• Very bad headache.
• This medicine may irritate the vein. If the drug leaks from the vein, it may also cause irritation around that area. Tell your nurse if you have any redness, burning, pain, swelling, or leaking of fluid where the drug is going into your body.

What are some other side effects of Amphotericin B?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Stomach pain or heartburn.
• Stomach cramps.
• Upset stomach or throwing up.
• Diarrhea.
• Not hungry.
• Headache.
• Muscle or joint pain.
• Feeling tired or weak.
• Weight loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Amphotericin B?

• If you need to store amphotericin B (conventional) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about amphotericin B (conventional), please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.