Uses of Naloxone Nasal Spray:

• It is used to avoid side effects from some drugs.
• It is used to treat some overdoses.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Naloxone Nasal Spray?

• If you are allergic to naloxone nasal spray; any part of naloxone nasal spray; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take naloxone nasal spray with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Naloxone Nasal Spray?

• Tell all of your health care providers that you take naloxone nasal spray. This includes your doctors, nurses, pharmacists, and dentists.
• If you are addicted to pain drugs and are given naloxone nasal spray, you may have signs of withdrawal. Talk with your doctor.
• In infants younger than 4 weeks old who have been getting opioid drugs on a regular basis, sudden withdrawal may be life-threatening if not treated right away. Get medical help right away if your child has a seizure, is crying more than normal, or has increased reflexes.
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
• If naloxone nasal spray is used during pregnancy, it may cause withdrawal in the unborn baby. A doctor will need to check on the unborn baby after naloxone nasal spray is used.

How is this medicine (Naloxone Nasal Spray) best taken?

Use naloxone nasal spray as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• For the nose only.
• Your doctor will teach you how to take naloxone nasal spray.
• Be sure you know how to use before an emergency happens. Read the package insert and instructions for use that come with naloxone nasal spray. If you have any questions about how to use naloxone nasal spray, talk with the doctor or pharmacist.
• Someone else may have to give naloxone nasal spray. Be sure others know where naloxone nasal spray is stored and how to give it if needed.
• After using naloxone nasal spray, overdose symptoms may go away and come back. It is important to get medical help right away after using naloxone nasal spray.
• Each nasal spray has only 1 dose and cannot be reused. If another dose is needed, you will need to use new nasal spray.
• If using more than 1 dose, switch nostrils with each dose.
• Do not use if naloxone nasal spray is out of date. Get a new one.
• If naloxone nasal spray freezes, you may let it thaw at room temperature before use. If an emergency happens and naloxone nasal spray is frozen, do not wait for it to thaw. Get medical help right away.

What do I do if I miss a dose?

• Get medical help right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
• Seizures.
• Shortness of breath.
• Chest pain or pressure.
• Fast or abnormal heartbeat.
• A burning, numbness, or tingling feeling that is not normal.
• Feeling agitated.
• Mood changes.
• Hallucinations (seeing or hearing things that are not there).
• Shakiness.
• Sweating a lot.

What are some other side effects of Naloxone Nasal Spray?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Muscle pain.
• Muscle spasm.
• Headache.
• Dry nose.
• Runny or stuffy nose.
• Swelling in the nose.
• Constipation.
• Tooth pain.
• Dry skin.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Naloxone Nasal Spray?

• Store in the original container at room temperature.
• Do not freeze.
• Protect from heat and light.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about naloxone nasal spray, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

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