Applies to tazemetostat: oral tablet.
Serious side effects of Tazemetostat
Along with its needed effects, tazemetostat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tazemetostat:
More common
- Bladder pain
- bleeding gums
- bloody or cloudy urine
- body aches or pain
- chest pain or tightness
- cough
- coughing up blood
- difficult, burning, or painful urination
- difficulty in breathing or swallowing
- dizziness
- ear congestion
- fever or chills
- frequent urge to urinate
- headache
- increased menstrual flow or vaginal bleeding
- loss of voice
- lower back or side pain
- muscle or bone pain
- nosebleeds
- pale skin
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- redness, itching, pain, swelling, tenderness, or warmth on the skin
- sneezing
- sore throat
- stuffy or runny nose
- unusual bleeding or bruising
- unusual tiredness or weakness
Less common
- Confusion
- fast heartbeat
- lightheadedness or fainting
- painful blisters on the trunk of the body
- rapid, shallow breathing
Rare
- General feeling of illness
- hoarseness
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- weight loss
- yellow skin and eyes
Other side effects of Tazemetostat
Some side effects of tazemetostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Constipation
- decreased appetite
- diarrhea
- hair loss or thinning
- nausea or vomiting
- skin rash
- stomach pain
For Healthcare Professionals
Applies to tazemetostat: oral tablet.
Hematologic
Very common (10% or more): Hemoglobin decreased (49%), decreased lymphocytes (36%), white blood cell count decreased (19%), hemorrhage (e.g., wound hemorrhage, rectal hemorrhage, pulmonary hemorrhage, hemorrhage intracranial, cerebral hemorrhage, hemoptysis) (18%), anemia (16%), partial thromboplastin time increased (15%)[Ref]
Metabolic
Very common (10% or more): Triglycerides increased (36%), glucose increased (33%), sodium decreased (30%), phosphate decreased (28%), anorexia (26%), albumin decreased (23%), alkaline phosphatase increased (23%), potassium decreased (20%), weight loss (16%), calcium decreased (16%), glucose decreased (16%), potassium increased (12%)[Ref]
Hepatic
Very common (10% or more): Aspartate aminotransferase increased (18%), alanine aminotransferase increased (14%)[Ref]
Oncologic
Uncommon (0.1% to 1%): Secondary malignancies (e.g., myelodysplastic syndrome [MDS], acute myeloid leukemia [AML])[Ref]
Respiratory
Very common (10% or more): Cough (18%), dyspnea/dyspnea exertional (16%)[Ref]
Other
Very common (10% or more): Pain (e.g., tumor pain, pain in extremity, non-cardiac chest pain, flank pain, back pain, arthralgia, bone pain, cancer pain, musculoskeletal pain, myalgia, neck pain) (52%), fatigue/asthenia (47%)[Ref]
General
The most common adverse reactions (20% or greater) were pain, fatigue, nausea, decreased appetite, vomiting, and constipation.[Ref]
Nervous system
Very common (10% or more): Headache (18%)[Ref]
Renal
Very common (10% or more): Creatinine increased (14%)[Ref]
Gastrointestinal
Very common (10% or more): Nausea (36%), vomiting (24%), constipation (21%), diarrhea (16%), abdominal pain (13%)[Ref]
