Applies to cycloserine: oral capsule.
Serious side effects of Cycloserine
Along with its needed effects, cycloserine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cycloserine:
More common
- Anxiety
- confusion
- dizziness
- drowsiness
- increased irritability
- increased restlessness
- mental depression
- muscle twitching or trembling
- nervousness
- nightmares
- other mood or mental changes
- speech problems
- thoughts of suicide
Less common
- Convulsions (seizures)
- numbness, tingling, burning pain, or weakness in the hands or feet
- skin rash
Other side effects of Cycloserine
Some side effects of cycloserine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Headache
For Healthcare Professionals
Applies to cycloserine: oral capsule.
General
The most commonly reported side effects included hypersensitivity and nervous system manifestations.[Ref]
Nervous system
Character changes, coma, convulsions, drowsiness, headache, hyperreflexia, major and minor (localized) clonic seizures, memory loss, paresis, paresthesia, somnolence, tremor, vertigo appeared to be dose related.[Ref]
Frequency not reported: Central nervous system toxicity, character changes, coma, convulsions, drowsiness, headache, hyperreflexia, major and minor (localized) clonic seizures, memory loss, paresis, paresthesia, somnolence, tremor, vertigo[Ref]
Psychiatric
Frequency not reported: Aggression, anxiety, confusion, disorientation, dysarthria, hyperirritability, psychosis with/without suicidal tendencies[Ref]
Aggression, confusion, disorientation, dysarthria, hyperirritability, and psychosis with/without suicidal tendencies appeared to be dose related.[Ref]
Hypersensitivity
Frequency not reported: Allergic dermatitis, allergy, drug hypersensitivity[Ref]
Hematologic
Frequency not reported: Megaloblastic anemia, sideroblastic anemia[Ref]
Metabolic
Frequency not reported: Folic acid deficiency, vitamin B12 deficiency[Ref]
Dermatologic
Frequency not reported: Rash/skin rash[Ref]
Cardiovascular
Sudden onset of congestive heart failure occurred in patients given 1000 to 1500 mg/day.[Ref]
Frequency not reported: Congestive heart failure[Ref]
Hepatic
Frequency not reported: Elevated serum transaminases[Ref]
Elevated serum transaminases occurred in patients with preexisting liver disease.[Ref]
