Usual Adult Dose for Hyperlipidemia

Initial dose: 40 mg of pravastatin with either 81 mg or 325 mg of buffered aspirin orally once a day. In the event a patient requires a lower dosage of pravastatin, aspirin-pravastatin is also available with 20 mg of pravastatin.
Maintenance dose: the pravastatin component may be increased to 80 mg orally once a day (with 81 mg or 325 mg of buffered aspirin) if the desired cholesterol levels are not achieved.

It is recommended that this drug be taken with a full glass of water, unless the patient is fluid restricted.

Usual Adult Dose for Myocardial Infarction - Prophylaxis

Initial dose: 40 mg of pravastatin with either 81 mg or 325 mg of buffered aspirin orally once a day. In the event a patient requires a lower dosage of pravastatin, aspirin-pravastatin is also available with 20 mg of pravastatin.
Maintenance dose: the pravastatin component may be increased to 80 mg orally once a day (with 81 mg or 325 mg of buffered aspirin) if the desired cholesterol levels are not achieved.

It is recommended that this drug be taken with a full glass of water, unless the patient is fluid restricted.

Usual Adult Dose for Revascularization Procedures - Prophylaxis

Initial dose: 40 mg of pravastatin with either 81 mg or 325 mg of buffered aspirin orally once a day. In the event a patient requires a lower dosage of pravastatin, aspirin-pravastatin is also available with 20 mg of pravastatin.
Maintenance dose: the pravastatin component may be increased to 80 mg orally once a day (with 81 mg or 325 mg of buffered aspirin) if the desired cholesterol levels are not achieved.

It is recommended that this drug be taken with a full glass of water, unless the patient is fluid restricted.

Usual Adult Dose for Ischemic Stroke - Prophylaxis

Initial dose: 40 mg of pravastatin with either 81 mg or 325 mg of buffered aspirin orally once a day. In the event a patient requires a lower dosage of pravastatin, aspirin-pravastatin is also available with 20 mg of pravastatin.
Maintenance dose: the pravastatin component may be increased to 80 mg orally once a day (with 81 mg or 325 mg of buffered aspirin) if the desired cholesterol levels are not achieved.

It is recommended that this drug be taken with a full glass of water, unless the patient is fluid restricted.

Renal Dose Adjustments

Aspirin-pravastatin is not recommended for use in patients with severe renal dysfunction.

Liver Dose Adjustments

Aspirin-pravastatin is not recommended for use in patients with severe hepatic impairment.

Dialysis

Data not available